[Taufon use in myopic contact lens wearers].

Abstract

PURPOSE:

To investigate the potential clinical efficacy of Taufon eye drops in silicone hydrogel soft contact lens wearers with nonprogressive myopia.

MATERIAL AND METHODS:

A total of 90 patients with non-progressive myopia aged from 28 to 45 years were divided in 3 homogeneous groups (30 patients in each). For vision correction silicone hydrogel Air Optix Night & Day ("Ciba Vision") and Pure Vision 2HD ("Bausch & Lomb") contact lenses were used. The average period of contact lens wear was 5.5 +/- 3.3 years. Apart from conventional ophthalmic assessment, all patients underwent a complex lacrimal system examination, which included Schirmer's test and tear film break-up time (TBUT). The Ocular Surface Disease Index (OSDI) was used for dry eye symptoms assessment. The condition of the corneal epithelium was evaluated after 0.2% fluorescein instillation. Group 1 patients received 4% Taufon eye drops, group 2--natural tears ("Alcon"). Group 3 patients did not use any eye drops at all.

RESULTS:

Baseline Schirmer's test results, TBUT, and OSDI score were similar in all groups (p < 0.05, Mann-Whitney test). Drug therapy was considered effective if Schirmer's test result remained > 10 mm, TBUT--not less than 10 sec, OSDI--not more than 15, there were positive dynamics or at least no negative changes in dry eye signs and symptoms. The patients from group 1 presented no subjective complaits and their corneal and conjunctival changes were less significant than that in other groups (p < 0.05). Regression of dry eye signs at biomicroscopy in this group was confirmed by Schirmer's test results, TBUT, and OSDI. In groups 2 and 3 dry eye sings were more pronounced.

CONCLUSION:

The study of the 4% Taufon eye drops efficacy for dry eye prevention in silicone hydrogel Air Optix Night & Day and Pure Vision 2HD contact lens wearers with non-progressive myopia showed that the clinical effect was more significant in the treatment group (group 1) as compared to both group 2 (natural tear) and 3 (p < 0.05).

• Authors: V V Naumenko, M A Pogosian, V P Sergeev
• Journal: Vestnik oftalmologii (Vestn Oftalmol) 2014 Jul-Aug Vol. 130 Issue 4 Pg. 97-8, 100-1 ISSN: 0042-465X [Print] Russia (Federation)
• PMID: 25306731 (Publication Type: English Abstract, Journal Article)

Chemical References

• Ophthalmic Solutions
• Silicone Gels
• Taurine

Topics

• Adult
• Contact Lenses, Hydrophilic (adverse effects)
• Diagnostic Techniques, Ophthalmological
• Drug Monitoring
• Dry Eye Syndromes (diagnosis, drug therapy, etiology, physiopathology)
• Female
• Humans
• Male
• Middle Aged
• Myopia (therapy)
• Ophthalmic Solutions (administration & dosage)
• Product Surveillance, Postmarketing
• Russia
• Silicone Gels
• Taurine (administration & dosage)
• Treatment Outcome