Therapeutic effects of metformin and laparoscopic ovarian drilling in treatment of clomiphene and insulin-resistant polycystic ovary syndrome.

Abstract

OBJECTIVE:

To compare the therapeutic effects of metformin (Met) and laparoscopic ovarian drilling (LOD) in clomiphene and insulin-resistant patients with polycystic ovary syndrome (CIRPCOS).

METHODS:

A total of 110 patients were randomly divided into two groups. One group was administered Met (n = 55), while the other group underwent LOD (n = 55). Rates of ovulation, pregnancy, and abortion were compared between both groups.

RESULTS:

Rates of normal menstruation, ovulation, and pregnancy in the LOD group were higher than in the Met group: 76.4% (42/55) vs. 58.2% (32/55), P < 0.04; 50.8% (11/258) vs. 33.5% (94/281), P < 0.001; 38.2% (21/55) vs. 20.0% (11/55), P < 0.03. The difference in the early abortion rate between both groups was not statistically significant.

CONCLUSIONS:

Although Met can significantly improve a patient's insulin resistance, we found that in patients diagnosed with CIRCPOS, LOD can be much more effective in improving rates of normal menstruation, ovulation, and pregnancy.

• Authors: Xiao-Hong Wang, Jun-Qing Wang, Yan Xu, Li-Ping Huang
• Journal: Archives of gynecology and obstetrics (Arch Gynecol Obstet) Vol. 291 Issue 5 Pg. 1089-94 (May 2015) ISSN: 1432-0711 [Electronic] Germany
• PMID: 25304269 (Publication Type: Journal Article, Randomized Controlled Trial, Retracted Publication)

Chemical References

• Hypoglycemic Agents
• Insulin
• Clomiphene
• Metformin

Topics

• Adult
• Clomiphene (therapeutic use)
• Female
• Humans
• Hypoglycemic Agents (therapeutic use)
• Insulin (therapeutic use)
• Insulin Resistance
• Laparoscopy
• Metformin (therapeutic use)
• Ovulation
• Ovulation Induction
• Polycystic Ovary Syndrome (blood, drug therapy, surgery)
• Pregnancy
• Primary Ovarian Insufficiency
• Treatment Outcome
• Young Adult