Pulmonary sarcoid-like granulomatosis after multiple vaccinations of a long-term surviving patient with metastatic melanoma.

Abstract

Autoimmune side effects are frequent in patients with cancer treated with immune checkpoint-targeting antibodies, but are rare with cancer vaccines. Here, we present a case report on a patient with metastatic melanoma who developed pulmonary sarcoid-like granulomatosis following repetitive vaccinations with peptides and CpG. Despite multiple metastases, including one lesion in the brain, the patient is alive and well more than 13 years after the diagnosis of metastatic disease. The strongly activated tumor-specific CD8(+) T cells showed robust long-term memory and effector functions. It is possible that long-term survival and adverse autoimmune events may become more common for vaccines inducing robust anticancer immune responses as were present in this patient.

• Authors: Natacha Bordry, Carla-Marisa Costa-Nunes, Laurène Cagnon, Philippe O Gannon, Samia Abed-Maillard, Petra Baumgaertner, Timothy Murray, Igor Letovanec, Romain Lazor, Hasna Bouchaab, Nathalie Rufer, Emanuela Romano, Olivier Michielin, Daniel E Speiser
• Journal: Cancer immunology research (Cancer Immunol Res) Vol. 2 Issue 12 Pg. 1148-53 (Dec 2014) ISSN: 2326-6074 [Electronic] United States
• PMID: 25277238 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: ©2014 American Association for Cancer Research.

Chemical References

• Antigens, Neoplasm
• Cancer Vaccines

Topics

• Adult
• Antigens, Neoplasm (immunology, metabolism)
• Autoimmunity
• Brain Neoplasms (diagnosis, secondary)
• Cancer Vaccines (administration & dosage, adverse effects)
• Humans
• Immunohistochemistry
• Lymphocytes, Tumor-Infiltrating (immunology, metabolism)
• Lymphomatoid Granulomatosis (diagnosis, etiology)
• Magnetic Resonance Imaging
• Male
• Melanoma (complications, diagnosis, immunology, therapy)
• Neoplasm Metastasis
• Positron-Emission Tomography
• Sarcoidosis, Pulmonary (diagnosis, etiology)
• Tomography, X-Ray Computed