Intraocular pressure decrease with preservative-free fixed and unfixed combination of tafluprost and timolol in pseudoexfoliative glaucoma.

Abstract

We investigated the intraocular pressure (IOP) lowering efficacy of preservative-free fixed and non-fixed combination of tafluprost 0.0015% and timolol 0.5% in pseudoexfoliative glaucoma (XFG). A per protocol worse eye analysis was made on all XFG patients who participated in a recent 6 month, prospective, randomized, double-masked, parallel group, multicenter phase III study. The mean time-wise IOP decreased by 8.62 to 10.25 mmHg (31.8 to 36.7%) in the fixed dose combination arm (15 patients) and by 5.38 to 11.35 mmHg (21.3 to 41.2%) in the non-fixed combination arm (13 patients), respectively (p < 0.001 for all comparisons). The results show that a preservative-free fixed dose combination of tafluprost and timolol provides a clinically significant IOP reduction in XFG, and may offer an advantage for the XFG patients with dry eye, due to its preservative-free nature.

• Authors: Gábor Holló, Auli Ropo
• Journal: Current medical research and opinion (Curr Med Res Opin) Vol. 31 Issue 1 Pg. 13-6 (Jan 2015) ISSN: 1473-4877 [Electronic] England
• PMID: 25275411 (Publication Type: Clinical Trial, Phase III, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Antihypertensive Agents
• Drug Combinations
• Preservatives, Pharmaceutical
• Prostaglandins F
• tafluprost
• Timolol

Topics

• Aged
• Antihypertensive Agents (administration & dosage)
• Double-Blind Method
• Drug Administration Schedule
• Drug Combinations
• Drug Therapy, Combination
• Female
• Glaucoma, Open-Angle (drug therapy)
• Humans
• Male
• Middle Aged
• Preservatives, Pharmaceutical
• Prospective Studies
• Prostaglandins F (administration & dosage)
• Timolol (administration & dosage)
• Treatment Outcome