Differential analgesic actions of serotonin 5-HT3 receptor antagonists in the mouse.

Abstract

The present study examined the analgesic effects of the serotonin 5-HT3 receptor antagonists ICS-205-930, MDL-7222 and GR-38032F in mice using acute thermal, mechanical and chemical pain tests. Subcutaneous administration (1-10 mg/kg) of these agents did not produce analgesia in either the thermal or mechanical pain tests. However, ICS-205-930, MDL-72222 and GR-38032F all produced dose-dependent analgesia in the chemical pain test, that was not altered by systemic naloxone administration (1 mg/kg, s.c.). Intracerebroventricular administration of these drugs (0.1-10 micrograms) was ineffective in producing analgesia in acute thermal, mechanical and chemical pain tests. These results suggest that peripheral 5-HT3 receptors play a role in chemical, but not thermal or mechanical nociceptive mechanisms.

• Authors: J Giordano, J Dyche
• Journal: Neuropharmacology (Neuropharmacology) Vol. 28 Issue 4 Pg. 423-7 (Apr 1989) ISSN: 0028-3908 [Print] England
• PMID: 2526302 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Analgesics
• Imidazoles
• Indoles
• Serotonin Antagonists
• Tropanes
• Naloxone
• Ondansetron
• Tropisetron
• bemesetron

Topics

• Analgesics
• Animals
• Imidazoles (administration & dosage, pharmacology)
• Indoles (administration & dosage, pharmacology)
• Injections, Intraventricular
• Male
• Mice
• Mice, Inbred C3H
• Naloxone (pharmacology)
• Nociceptors (drug effects)
• Ondansetron
• Pain Measurement
• Reaction Time (drug effects)
• Serotonin Antagonists (administration & dosage, pharmacology)
• Tropanes (administration & dosage, pharmacology)
• Tropisetron