Abstract | BACKGROUND: Diagnosis and treatment of tremor are largely based on clinical assessment. Whereas in some patients tremor may respond to dopaminergic treatment, in general l-Dopa response to tremor varies considerably. The aim of this study was to predict l-Dopa response by accelerometry. METHODS: We included 60 tremor patients and measured harmonic oscillations by accelerometry. In addition to neurological assessment, we performed l-Dopa challenge tests and the individual tremor response was compared to the amount of harmonic oscillations. RESULTS: We found a strong correlation between harmonic oscillations and clinical l-Dopa response. Similarly, harmonic oscillations were significantly greater in patients with subjective tremor reduction upon l-Dopa administration. CONCLUSIONS: We conclude that harmonic oscillations are a measure for l-Dopa response to tremor irrespective of the underlying disease. Because of the observational character of the study, any causal relation remains speculative. Nevertheless, we propose a novel, non-invasive approach to predict l-Dopa response in tremor patients.
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Authors | Lukas L Imbach, Michael Sommerauer, Kaspar Leuenberger, Sebastian R Schreglmann, Oliver Maier, Mechtild Uhl, Roger Gassert, Christian R Baumann |
Journal | Parkinsonism & related disorders
(Parkinsonism Relat Disord)
Vol. 20
Issue 11
Pg. 1283-6
(Nov 2014)
ISSN: 1873-5126 [Electronic] England |
PMID | 25260965
(Publication Type: Journal Article, Observational Study, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2014 Elsevier Ltd. All rights reserved. |
Chemical References |
- Antiparkinson Agents
- Levodopa
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Antiparkinson Agents
(therapeutic use)
- Female
- Humans
- Levodopa
(therapeutic use)
- Male
- Middle Aged
- Parkinson Disease
(drug therapy)
- Treatment Outcome
- Tremor
(drug therapy, physiopathology)
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