Genetic susceptibility to total hip arthroplasty failure: a case-control study on the influence of MMP 1 gene polymorphism.

Abstract

BACKGROUND:

Genetic factors plays an important role in early failure of total hip arthroplasty (THA) etiology and MMP-1 gene polymorphism rs5854 may be involved. The present study was conducted to reveal the possible association between MMP-1 rs5854 C/T polymorphism and the risk of early failure of THA (aseptic loosening).

METHODS:

The rs5854 single nucleotide polymorphism (SNP) in MMP-1 gene was genotyped in 63 subjects who were diagnosed as aseptic loosening after total hip arthroplasty within 10 years and in 81 age and gender matched controls.

RESULTS:

The genotype frequencies of the MMP-1 rs5854 C/T polymorphism were 57.1% (CC), 28.6% (CT), and 14.3% (TT) in patients with failure of THA, and 79.0% (CC), 17.3% (CT), and 3.7% (TT) in the controls (P=0.0099). Rs5854 polymorphism was found to be significantly associated with increased risk of aseptic loosening.

CONCLUSION:

The results showed the rs5854 SNP was associated with increased risk of the early aseptic loosening susceptibility.

VIRTUAL SLIDES:

The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/13000_2014_177.

• Authors: Yiguo Yan, Jianzhong Hu, Hongbin Lu, Wenjun Wang
• Journal: Diagnostic pathology (Diagn Pathol) Vol. 9 Pg. 177 (Sep 26 2014) ISSN: 1746-1596 [Electronic] England
• PMID: 25257555 (Publication Type: Journal Article)

Chemical References

• Matrix Metalloproteinase 1

Topics

• Aged
• Aged, 80 and over
• Alleles
• Arthroplasty, Replacement, Hip (adverse effects)
• Asian People (genetics)
• Case-Control Studies
• China
• Female
• Genetic Predisposition to Disease (genetics)
• Genotype
• Hip Prosthesis
• Humans
• Male
• Matrix Metalloproteinase 1 (genetics)
• Middle Aged
• Polymorphism, Single Nucleotide (genetics)
• Prosthesis Failure (etiology)
• Risk Factors
• Treatment Failure