CHA2DS2-VASc score is a useful-predictor of not prognosis but coronary-arteriosclerosis in chronic atrial-fibrillation compared with CHADS2 score: a two-center study of 320-slice CT, part 2.

Abstract

BACKGROUND:

The aim of this study is to predict the risk of coronary-arteriosclerosis and prognosis in subjects with chronic-atrial-fibrillation (CAF) using the CHADS2 and CHA2DS2-VASc scores by 320-slice-CT and invasive-coronary-angiography (ICA) in a two-center-study.

METHODS:

53 CAF subjects who underwent 320-slice-CT and ICA within 6-months (43 male; 69 ± 9 years; CHADS2 score 2.2 ± 1.3; CHA2DS2-VASc score 3.5 ± 1.6) in the two-institutes were analyzed. CT and ICA data were transferred to the analysis-center and were analyzed by cardiologists.

RESULTS:

Agatston-calcium-score and frequencies of the presence of various-kinds of plaques and >50% and >75% coronary artery stenosis were significantly higher in the subjects with CHA2DS2-VASc score ≥ 3 compared with those with score <3. However there were no-significant differences in the Agatston-calcium-score and frequencies of the presence of various-kinds of plaques and >50% and >75% coronary artery stenosis evaluated by 320-slice CT between the subjects with CHADS2 score ≥ 2 and <2. Frequency of >50% coronary artery stenosis by ICA was significantly higher in the subjects with CHA2DS2-VASc score ≥ 3 compared with those with score <3. However, there were no-significant differences in the frequencies of >50% and >75% coronary artery stenosis by ICA between the subjects with CHADS2 score ≥ 2 and <2. During a mean of 15.9 months, composite rate of cardiac death and heart failure did not differ between subjects with CHADS2 score ≥ 2 and score <2 and between subjects with CHA2DS2-VASc score ≥ 3 and score <3.

CONCLUSIONS:

The CHA2DS2-VASc score is a useful predictor of not prognosis but coronary-arteriosclerosis in subjects with CAF compared with CHADS2 score in this two-center-study.

• Authors: Masae Uehara, Nobusada Funabashi, Hiroyuki Takaoka, Koya Ozawa, Shunichi Kushida, Junji Kanda, Yoshihide Fujimoto, Yoshio Kobayashi
• Journal: International journal of cardiology (Int J Cardiol) Vol. 177 Issue 2 Pg. 368-73 (Dec 15 2014) ISSN: 1874-1754 [Electronic] Netherlands
• PMID: 25245494 (Publication Type: Comparative Study, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Topics

• Aged
• Aged, 80 and over
• Atrial Fibrillation (complications, diagnostic imaging)
• Chronic Disease
• Coronary Artery Disease (complications, diagnostic imaging)
• Female
• Follow-Up Studies
• Humans
• Male
• Middle Aged
• Multidetector Computed Tomography (standards)
• Predictive Value of Tests
• Prognosis
• Retrospective Studies
• Severity of Illness Index