Altered erythrocyte membrane fatty acid profile in typical Rett syndrome: effects of omega-3 polyunsaturated fatty acid supplementation.

Abstract

This study mainly aims at examining the erythrocyte membrane fatty acid (FAs) profile in Rett syndrome (RTT), a genetically determined neurodevelopmental disease. Early reports suggest a beneficial effects of omega-3 polyunsaturated fatty acids (ω-3 PUFAs) on disease severity in RTT. A total of 24 RTT patients were assigned to ω-3 PUFAs-containing fish oil for 12 months in a randomized controlled study (average DHA and EPA doses of 72.9, and 117.1mg/kgb.w./day, respectively). A distinctly altered FAs profile was detectable in RTT, with deficient ω-6 PUFAs, increased saturated FAs and reduced trans 20:4 FAs. FAs changes were found to be related to redox imbalance, subclinical inflammation, and decreased bone density. Supplementation with ω-3 PUFAs led to improved ω-6/ω-3 ratio and serum plasma lipid profile, decreased PUFAs peroxidation end-products, normalization of biochemical markers of inflammation, and reduction of bone hypodensity as compared to the untreated RTT group. Our data indicate that a significant FAs abnormality is detectable in the RTT erythrocyte membranes and is partially rescued by ω-3 PUFAs.

• Authors: Cinzia Signorini, Claudio De Felice, Silvia Leoncini, Thierry Durand, Jean-Marie Galano, Alessio Cortelazzo, Gloria Zollo, Roberto Guerranti, Stefano Gonnelli, Carla Caffarelli, Marcello Rossi, Alessandra Pecorelli, Giuseppe Valacchi, Lucia Ciccoli, Joussef Hayek
• Journal: Prostaglandins, leukotrienes, and essential fatty acids (Prostaglandins Leukot Essent Fatty Acids) Vol. 91 Issue 5 Pg. 183-93 (Nov 2014) ISSN: 1532-2823 [Electronic] Scotland
• PMID: 25240461 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2014 Elsevier Ltd. All rights reserved.

Chemical References

• Biomarkers
• Fatty Acids, Omega-3
• Isoprostanes
• Lipids
• Docosahexaenoic Acids
• Eicosapentaenoic Acid

Topics

• Adolescent
• Adult
• Animals
• Biomarkers (blood)
• Child
• Child, Preschool
• Dietary Supplements
• Docosahexaenoic Acids (administration & dosage, metabolism)
• Eicosapentaenoic Acid (administration & dosage, metabolism)
• Erythrocyte Membrane (drug effects, metabolism, pathology)
• Fatty Acids, Omega-3 (administration & dosage, metabolism)
• Female
• Humans
• Inflammation (metabolism, pathology)
• Isoprostanes (blood)
• Lipids (blood)
• Rett Syndrome (diet therapy, metabolism, pathology)