Abstract | OBJECTIVE: METHODS: Study population consisted of 212 hFH and 147 FCH patients that visited Lipid Outpatient Department (mean follow up of 11 and 10 years respectively). Several clinical data such as history of DM, cardiovascular disease, thyroid function, metabolic syndrome, glucose levels, lipid profile and lifestyle data were obtained. In order to compare the effects of different doses of different types of statins, a " statin treatment intensity product" was used. RESULTS: 14% of FCH and only 1% of hFH patients developed DM during follow up. Although univariate analysis showed a statistical trend (p = 0.06) in the association between new onset DM and statin treatment intensity ( STI) in the FCH subgroup of patients with normal baseline glucose levels, this was no longer significant after adjusting for several confounders. Furthermore, the type of statins used did not seem to play a role in the development of DM either in hFH or FCH patients. CONCLUSION: Long duration of high STI does not seem to be associated with diabetic risk in hFH patients. High STI used in the FCH population is not associated with increased risk of new onset DM compared to low STI. Further studies are required in order to clarify the potential diabetogenic effects of statins in these high risk populations.
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Authors | John Skoumas, Catherine Liontou, Christina Chrysohoou, Constantina Masoura, Konstantinos Aznaouridis, Christos Pitsavos, Christodoulos Stefanadis |
Journal | Atherosclerosis
(Atherosclerosis)
Vol. 237
Issue 1
Pg. 140-5
(Nov 2014)
ISSN: 1879-1484 [Electronic] Ireland |
PMID | 25238223
(Publication Type: Journal Article)
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Copyright | Copyright © 2014 Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
- Blood Glucose
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
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Topics |
- Adult
- Anthropometry
- Blood Glucose
(chemistry)
- Blood Pressure
- Diabetes Complications
(drug therapy)
- Diabetes Mellitus
(drug therapy)
- Female
- Heterozygote
- Humans
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
(adverse effects, therapeutic use)
- Hyperlipidemia, Familial Combined
(complications, drug therapy, genetics)
- Hyperlipidemias
(complications, drug therapy, genetics)
- Incidence
- Life Style
- Male
- Middle Aged
- Proportional Hazards Models
- Prospective Studies
- Risk Factors
- Treatment Outcome
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