Hypoadiponectinemia as an independent predictor for the progression of carotid atherosclerosis: a 5-year prospective study.

Abstract

BACKGROUND:

Hypoadiponectinemia predicts the development of diabetes and hypertension, both being potent atherosclerotic risk factors. Whether adiponectin predicts the progression of early atherosclerosis remains unclear. In this 5-year prospective study, we examined the relationship between serum adiponectin and carotid intima media thickness (CIMT), a marker of subclinical atherosclerosis.

METHODS:

A total of 265 subjects from the population-based Hong Kong Cardiovascular Risk Factor Prevalence Study, with no known cardiovascular disease, underwent CIMT measurement at baseline and at 5 years.

RESULTS:

In all, 129 men and 136 women, aged 54.6±12.3 years, were studied. Median CIMT at baseline was 0.63 mm (interquartile range 0.52-0.73 mm) and increased to 0.67 mm (0.56-0.78 mm) after 5 years (P<0.001). CIMT increment correlated with baseline adiponectin, age, and smoking (all P<0.05) and baseline CIMT (P<0.001), but not with sex, fasting glucose, lipid profiles, hypertension, or diabetes. In multiple linear regression analysis, baseline serum adiponectin level was an independent predictor of CIMT increment β (standardized beta)=-0.17, P=0.015], after adjusting for age, smoking, baseline CIMT, hypertension, body mass index, fasting glucose, low-density lipoprotein cholesterol, and triglycerides.

CONCLUSION:

Hypoadiponectinemia predicted CIMT progression, independent of known predictive factors such as age, smoking, hyperlipidemia, and hypertension.

• Authors: Elaine Hui, Aimin Xu, Wing-Sun Chow, Paul C H Lee, Carol H Y Fong, Stephen C W Cheung, Hung Fat Tse, Ming-Tak Chau, Bernard M Y Cheung, Karen S L Lam
• Journal: Metabolic syndrome and related disorders (Metab Syndr Relat Disord) Vol. 12 Issue 10 Pg. 517-22 (Dec 2014) ISSN: 1557-8518 [Electronic] United States
• PMID: 25211296 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• ADIPOQ protein, human
• Adiponectin
• Biomarkers

Topics

• Adiponectin (blood, deficiency)
• Adult
• Aged
• Biomarkers (blood)
• Carotid Artery Diseases (blood, diagnostic imaging, epidemiology)
• Carotid Intima-Media Thickness
• Disease Progression
• Down-Regulation
• Female
• Hong Kong (epidemiology)
• Humans
• Male
• Metabolism, Inborn Errors (blood, diagnosis, epidemiology)
• Middle Aged
• Predictive Value of Tests
• Prevalence
• Prospective Studies
• Risk Factors
• Time Factors