Prognostic role of vascular endothelial growth factor and its receptor-1 in patients with esophageal cancer.
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| Abstract | BACKGROUND/AIM: To present long-term results regarding the role of vascular endothelial growth factor (VEGF) and its receptor-1 (VEGFR-1) for esophageal cancer. PATIENTS AND METHODS: In 68 esophageal cancer patients, VEGF, VEGFR-1 plus ten other factors were analyzed for locoregional control (LRC), metastases-free survival (MFS) and survival up to 10 years. RESULTS: On multivariate analysis, improved LRC was associated with hemoglobin during radiotherapy ≥12 g/dl (p=0.001). VEGF-negativity showed a trend for better LRC on univariate analysis. On multivariate analysis, better MFS was associated with hemoglobin ≥12 g/dl (p=0.012), better performance status (p=0.009) and lower tumor stage (p=0.032). On multivariate analysis, improved survival was associated with hemoglobin ≥12 g/dl (p<0.001) and better performance status (p=0.005). Trends for improved survival were observed for VEGF-negativity and VEGFR-1-negativity on univariate analysis. CONCLUSION:
VEGF showed a trend towards worse LRC and survival, VEGFR-1 towards worse survival. Outcomes were associated with hemoglobin, performance status and tumor stage.
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| Authors | Ergin Kilic, Steven E Schild, Christoph Thorns, Amira Bajrovic, Dirk Rades |
| Journal | Anticancer research (Anticancer Res) Vol. 34 Issue 9 Pg. 5221-6 (Sep 2014) ISSN: 1791-7530 [Electronic] Greece |
| PMID | 25202119 (Publication Type: Journal Article) |
| Copyright | Copyright© 2014 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved. |
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