Abstract | BACKGROUND: Up to present no curative treatment is known for Dupuytren's disease (DD). Surgery remains the most common treatment but lack of long-term efficacy and complications limit this therapeutic option. OBJECTIVE: In a retrospective analysis, the results of radiotherapy with soft X-rays in the treatment of DD were evaluated. METHODS: A total of 206 patients (297 affected hands) with DD were included. Radiation therapy was carried out with soft X-rays. A structured questionnaire considering patient and disease characteristics and effects of radiotherapy was evaluated after a median follow-up time of 40 months. RESULTS: Ninety-three (45%) of the 206 treated patients were reported on a regression of symptoms after radiation. No further disease progression (including patients with regression) was present in 165 patients (80%). Satisfaction with the therapy was expressed with an average score of 7.9 points (visual analogue scale, 0 = not satisfied, 10 = extremely satisfied). Subjective therapeutic effects for 426 nodules and/or cords showed a reduction of 92 nodules and/or cords. CONCLUSION: In 206 DD patients further disease progression was stopped in most patients. Radiotherapy proved to be well-tolerated, successful and satisfying for the patients.
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Authors | M Zirbs, T Anzeneder, H Bruckbauer, H Hofmann, K Brockow, J Ring, B Eberlein |
Journal | Journal of the European Academy of Dermatology and Venereology : JEADV
(J Eur Acad Dermatol Venereol)
Vol. 29
Issue 5
Pg. 904-11
(May 2015)
ISSN: 1468-3083 [Electronic] England |
PMID | 25201324
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2014 European Academy of Dermatology and Venereology. |
Topics |
- Dupuytren Contracture
(genetics, radiotherapy)
- Female
- Humans
- Male
- Middle Aged
- Patient Satisfaction
- Radiotherapy
(adverse effects)
- Retrospective Studies
- Surveys and Questionnaires
- Treatment Outcome
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