Abstract | STUDY OBJECTIVE: DESIGN: Prospective randomized, double-blinded study. SETTING: Operating room and Postanesthesia Care Unit of a university hospital. PATIENTS: 80 ASA physical status 1 and 2 women scheduled for elective breast cancer surgery. INTERVENTIONS: Patients were randomly allocated to two groups in double-blinded fashion: Group B ( betamethasone; 37 pts) and Group C (control; 38 pts). Group B received 8 mg of betamethasone intravenously before the start of surgery. MEASUREMENTS: MAIN RESULTS: There was a significant lower incidence of postoperative nausea (PON) scoring NRS ≥ 1 in Group B in the 4 to 12-hour period compared with Group C (P = 0.02). The cumulative incidence of PON was 57% in Group B versus 68% in Group C (P = 0.27). The overall incidence of postoperative vomiting (POV) was 18% and 20% in Groups B and C, respectively. Postoperative pain was reduced by 40% in Group B in the 4 to 12-hour period, but the mean dose of postoperative rescue analgesic did not differ between the groups. CONCLUSIONS: Preoperative betamethasone reduces the severity of PONV and pain in patients undergoing elective breast surgery.
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Authors | Knut J Olanders, Gerd A E Lundgren, Anders M G Johansson |
Journal | Journal of clinical anesthesia
(J Clin Anesth)
Vol. 26
Issue 6
Pg. 461-5
(Sep 2014)
ISSN: 1873-4529 [Electronic] United States |
PMID | 25195060
(Publication Type: Journal Article, Randomized Controlled Trial)
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Copyright | Copyright © 2014 Elsevier Inc. All rights reserved. |
Chemical References |
- Antiemetics
- Betamethasone
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Topics |
- Adult
- Aged
- Antiemetics
(therapeutic use)
- Betamethasone
(therapeutic use)
- Breast Neoplasms
(surgery)
- Double-Blind Method
- Female
- Humans
- Mastectomy, Segmental
- Middle Aged
- Pain Measurement
(methods)
- Pain, Postoperative
(prevention & control)
- Postoperative Nausea and Vomiting
(prevention & control)
- Preanesthetic Medication
(methods)
- Prospective Studies
- Severity of Illness Index
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