Goldilocks, vitamin D and sarcoidosis.

Abstract

While low levels of vitamin D can increase the risk for osteoporosis, excessive amounts of vitamin D may also be problematic. Hypercalcemia and hypercalcuria due to increased vitamin D activity occur in a significant proportion of sarcoidosis patients. Saidenberg-Kermanac’h and colleagues compared vitamin D levels with bone fragility fractures in their sarcoidosis clinic.They found that a 25-(OH) vitamin D level between 10 and 20 ng/ml was associated with the lowest risk of bone fractures and paradoxically higher levels increased the risk of bone fractures. Using less vitamin D supplementation may simultaneously lower the risk for bone fracture and hypercalcemia in sarcoidosis.

• Authors: Robert P Baughman, Elyse E Lower
• Journal: Arthritis research & therapy (Arthritis Res Ther) Vol. 16 Issue 3 Pg. 111 ( 2014) ISSN: 1478-6362 [Electronic] England
• PMID: 25166268 (Publication Type: Editorial, Comment)

Topics

• Calcium Metabolism Disorders (epidemiology)
• Female
• Humans
• Male
• Sarcoidosis (complications, metabolism)
• Spinal Fractures (epidemiology)