Abstract | OBJECTIVE: METHODS: An economic model was developed to estimate the per patient cost of managing grade 3/4 AEs for patients who were treated with EVE + EXE or chemotherapies. AE rates for patients receiving EVE + EXE were collected from the phase III BOLERO-2 trial. AE rates for single-agent chemotherapy, capecitabine, docetaxel, or doxorubicin were collected from published clinical trial data. AEs with at least 2% prevalence for any of the treatments were included in the model. A literature search was conducted to obtain costs of managing each AE, which were then averaged across Western European countries (when available). Per patient costs for managing AEs among patients receiving different therapies were reported in 2012 euros (€). RESULTS: CONCLUSIONS: The current model estimates that AE management during the treatment of HR+ advanced breast cancer will cost one-half to one-third less for EVE + EXE patients than for chemotherapy patients. The consideration of AE costs could have important implications in the context of healthcare spending for advanced breast cancer treatment.
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Authors | Mario Campone, Hongbo Yang, Elizabeth Faust, Andrew Kageleiry, James E Signorovitch, Jie Zhang, Haitao Gao |
Journal | Journal of medical economics
(J Med Econ)
Vol. 17
Issue 12
Pg. 837-45
(Dec 2014)
ISSN: 1941-837X [Electronic] England |
PMID | 25164472
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Androstadienes
- Antineoplastic Agents
- Everolimus
- exemestane
- Sirolimus
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Topics |
- Androstadienes
(administration & dosage, adverse effects, economics)
- Antineoplastic Agents
(administration & dosage, adverse effects, economics)
- Antineoplastic Combined Chemotherapy Protocols
(adverse effects, economics)
- Breast Neoplasms
(drug therapy)
- Databases, Factual
- Europe
- Everolimus
- Female
- Humans
- Models, Economic
- Sirolimus
(administration & dosage, adverse effects, analogs & derivatives, economics)
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