Intravenous flunitrazepam for status epilepticus.

Abstract

Flunitrazepam (FZP) was administered intravenously, with success, to two patients with status epilepticus. Case 1 was a patient with a tonic-clonic status epilepticus. Intravenous phenytoin had no effect. Case 2 had minor status epilepticus. With the intravenous administration of FZP, diluted 1:10 with distilled water at a dose of 0.03 mg/kg at a slow rate, both patients were relieved of the status epilepticus. Unlike diazepam, FZP neither looks cloudy when diluted with distilled water nor causes angialgia. No disturbances in circulation or respiration occurred. Considering that FZP has a strong anticonvulsant action on status epilepticus, it can be expected to be a useful therapeutic agent for status epilepticus in infants and children.

• Authors: K Sumi, T Nagaura, N Sakata, T Nishigaki, M Akagi
• Journal: Acta paediatrica Japonica : Overseas edition (Acta Paediatr Jpn) Vol. 31 Issue 5 Pg. 563-6 (Oct 1989) ISSN: 0374-5600 [Print] Australia
• PMID: 2515734 (Publication Type: Case Reports, Journal Article)

Chemical References

• Flunitrazepam

Topics

• Child
• Child, Preschool
• Electroencephalography
• Female
• Flunitrazepam (administration & dosage)
• Humans
• Injections, Intravenous
• Status Epilepticus (drug therapy)