[Efficacy of sulpiride and itopride in the treatment of functional dyspepsia in women with emotional and eating disorders].

Abstract

UNLABELLED:

Functional dyspepsia is often accompanied by emotional disturbances, especially in postmenopausal women. Impaired homeostasis of the dopaminergic system maybe one of the common pathogenetic factors. The aim of the study was to assess the effect of drugs which block dopamine D2 receptors on psychosomatic condition in postmenopausal women.

MATERIAL AND METHODS:

The study was conducted in a group of 60 women, aged 53-61 years, with postprandial distress syndrome (PDS) that met the Rome Criteria III. The severity of dyspeptic symptoms was determined statistically using a 10-point Visual Analogue Scale (VAS). The emotional state was estimated with the Hamilton Anxiety Rating Scale (HARS) and the Beck Depression Inventory (BDI), whereas the body mass index (BMI) was the indicator of the nutritional status. Sulpiride (2 x 50 mg) was administered to 30 women for 16 weeks and itopride (2 x 50 mg) to 30 others.

RESULTS:

After sulpiride and itopride treatment equal decrease of dyspeptic symptoms was observed, respectively from 9.08 to 4.76 pts and from 9.02 to 4.64 pts. Significant reduction in the level of anxiety (p < 0.001) and depression (p < 0.01) was obtained in both groups, slightly higher after sulpiride. However, no significant change in BMI was found.

CONCLUSIONS:

Sulpiride and itopride are effective in the treatment of dyspepsia in the form of postprandial distress syndrome. These drugs in the several-month treatment have no significant effect on body weight.

• Authors: Patrycja Wachowska-Kelly, Ewa Walecka-Kapica, Paweł Wojtkiewicz, Monika Pawłowicz, Grazyna Klupińska, Cezary Chojnacki
• Journal: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego (Pol Merkur Lekarski) Vol. 37 Issue 217 Pg. 39-42 (Jul 2014) ISSN: 1426-9686 [Print] Poland
• Vernacular Title: Ocena skuteczności sulpirydu i itoprydu w leczeniu dyspepsji czynnościowej u kobiet z zaburzeniami emocji i łaknienia.
• PMID: 25154198 (Publication Type: Clinical Trial, English Abstract, Journal Article)

Chemical References

• Benzamides
• Benzyl Compounds
• Dopamine Antagonists
• Receptors, Dopamine D2
• Sulpiride
• itopride

Topics

• Aged
• Anxiety Disorders (complications, diagnosis)
• Benzamides (therapeutic use)
• Benzyl Compounds (therapeutic use)
• Depression (complications, diagnosis)
• Dopamine Antagonists (therapeutic use)
• Dyspepsia (drug therapy, etiology)
• Feeding and Eating Disorders (complications)
• Female
• Humans
• Middle Aged
• Personality Inventory
• Postprandial Period
• Receptors, Dopamine D2 (drug effects)
• Sulpiride (therapeutic use)