Brain magnetic resonance immediately before surgery in single ventricles and surgical postponement.

Abstract

BACKGROUND:

Single-ventricle patients undergoing surgical reconstruction experience a high rate of brain injury. Incidental findings on preoperative brain scans may result in safety considerations involving hemorrhage extension during cardiopulmonary bypass that result in surgical postponement.

METHODS:

Single-ventricle patients were studied with brain scans immediately preoperatively, as part of a National Institutes of Health study, and were reviewed by neuroradiology immediately before cardiopulmonary bypass.

RESULTS:

Of 144 consecutive patients recruited into the project, 33 were studied before stage I (3.7±1.8 days), 34 before bidirectional Glenn (5.8±0.5 months), and 67 before Fontan (3.3±1.1 years) operations. Six operations (4.5%), 2 before stage I, 3 before bidirectional Glenn, and 1 before Fontan, were postponed because of concerning findings on brain magnetic resonance imaging. Five were due to unexpected incidental findings of acute intracranial hemorrhage, and 1 was due to diffuse cerebellar cytotoxic edema; none who proceeded to operation had these lesions. Prematurity and genetic syndromes were not present in any patients with a postponed operation. Four of 4 before bidirectional Glenn/Fontan with surgical delays had hypoplastic left heart syndrome compared with 44 of 97 who did not (p=0.048). After observation and follow-up, all eventually had successful operations with bypass.

CONCLUSIONS:

Preoperative brain magnetic resonance imaging performed in children with single ventricles disclosed injuries in 4.5% leading to surgical delay; hemorrhagic lesions were most common and raised concerns for extension during the operation. The true risk of progression and need for delay of the operation due to heparinization associated with these lesions remains uncertain.

• Authors: Mark A Fogel, Tom Pawlowski, Peter J Schwab, Susan C Nicolson, Lisa M Montenegro, Laura Diaz Berenstein, Thomas L Spray, J William Gaynor, Stephanie Fuller, Marc S Keller, Matthew A Harris, Kevin K Whitehead, Arastoo Vossough, Daniel J Licht
• Journal: The Annals of thoracic surgery (Ann Thorac Surg) Vol. 98 Issue 5 Pg. 1693-8 (Nov 2014) ISSN: 1552-6259 [Electronic] Netherlands
• PMID: 25149046 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2014 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.

Topics

• Brain (pathology)
• Brain Ischemia (diagnosis, epidemiology, etiology)
• Cardiac Surgical Procedures (adverse effects, methods)
• Child, Preschool
• Female
• Heart Ventricles (abnormalities, surgery)
• Humans
• Hypoplastic Left Heart Syndrome (surgery)
• Incidence
• Infant
• Infant, Newborn
• Intracranial Hemorrhages (diagnosis, epidemiology, etiology)
• Magnetic Resonance Imaging (methods)
• Male
• Pennsylvania (epidemiology)
• Preoperative Period
• Reproducibility of Results
• Risk Factors
• Survival Rate (trends)
• Treatment Outcome