Abstract | BACKGROUND: OBJECTIVES: This study is designed to compare the S. aureus super antigens level in sera of psoriatic patients with normal cases ( nevus). PATIENTS AND METHODS: A case control study was performed in dermatology ward of Rasoul Hospital in Tehran, IR Iran (2008 - 2010). Staphylococcal super antigens (Entrotoxin A, B, D and TSST1) were measured in serum of 41 psoriatic patients and 28 normal persons ( Nevus) by ELISA. Chi square values (CI 95%, P value < 0.05) were calculated for all categorical variables. RESULTS: In this study 63.4% (26) of cases were male, 36.6% (15) were female. Age ranged from 4 months to 64 years old, with a mean age of 33.7 ± 15.4 years. Type of skin disease in cases: 20% (8) were inflicted by the Gutate form of the disease; 59% (23) with chronic plaque psoriasis ( CPP), 7.7% (3) with erythrodermic and 12.8% (5) had other types of the disease (plaque, pustular, inverse). TSST ( toxic shock syndrome toxin) was detected in 47% (20/41) of cases and in 6% (1/28) of the controls with a significant difference. (P value = 0.000) Entrotoxins (A, B, D) were detected in the sera of 48.8% (21/41) of cases; and only 6 %( 1/21) of controls, showed significant differences (P value = 0.000) positive TSST was more common in spring, and correlates with CPP type of psoriasis, but not related to patient`s gender and age. CONCLUSIONS: In this study, S. aureus were 25 times more in psoriatic patients. Super antigens should be first detected in the serum samples; if negative, the skin lesions should be examined by PCR especially in chronic types of disease. Adding the antibiotics against S. aureus to other conventional treatments might be helpful. It has a more important and significant role in children with acuteinfection.
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Authors | Najmolsadat Atefi, Samileh Noorbakhsh, Sahar Ghavidel Darestani, Azardokht Tabatabaei, Mohammadreza Rezaee |
Journal | Jundishapur journal of microbiology
(Jundishapur J Microbiol)
Vol. 7
Issue 5
Pg. e9912
(May 2014)
ISSN: 2008-3645 [Print] Netherlands |
PMID | 25147719
(Publication Type: Journal Article)
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