Abstract | PURPOSE: Optic nerve inflammation, demyelination, and axonal loss are all prominent features of optic neuritis. While corticosteroids hasten visual recovery in optic neuritis, no treatment improves final visual outcomes. HE3286 (17α-ethynyl-5-androstene-3β,7β,17β-triol), a synthetic derivative of a natural steroid, β- AET (5-androstene-3β,7β,17β-triol), exerts anti-inflammatory effects in several disease models and has purported neuroprotective effects as well. HE3286's ability to suppress optic neuritis was examined in experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis. METHODS: RESULTS: Progressive decreases in OKR occurred in vehicle-treated EAE mice, and HE3286 treatment reduced the level of this vision loss. HE3286 also attenuated the degree of inflammation, demyelination, and axonal loss in EAE optic nerves as compared to nerves from vehicle-treated EAE mice. Retinal ganglion cell loss that occurred in both vehicle- and HE3286-treated EAE mice was reduced in the temporal retinal quadrant of HE3286-treated mice. CONCLUSIONS:
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Authors | Reas S Khan, Kimberly Dine, Esteban Luna, Clarence Ahlem, Kenneth S Shindler |
Journal | Investigative ophthalmology & visual science
(Invest Ophthalmol Vis Sci)
Vol. 55
Issue 9
Pg. 5744-51
(Aug 19 2014)
ISSN: 1552-5783 [Electronic] United States |
PMID | 25139738
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | Copyright 2014 The Association for Research in Vision and Ophthalmology, Inc. |
Chemical References |
- 17-ethynyl-5-androstene-3, 7, 17-triol
- Anti-Inflammatory Agents
- Neuroprotective Agents
- Dehydroepiandrosterone
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Topics |
- Animals
- Anti-Inflammatory Agents
(therapeutic use)
- Axons
(drug effects, pathology)
- Dehydroepiandrosterone
(analogs & derivatives, therapeutic use)
- Disease Models, Animal
- Encephalomyelitis, Autoimmune, Experimental
(drug therapy, pathology)
- Female
- Mice
- Mice, Inbred C57BL
- Neuroprotective Agents
(therapeutic use)
- Optic Neuritis
(drug therapy, pathology)
- Retinal Ganglion Cells
(drug effects, pathology)
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