Abstract | BACKGROUND: METHODS: To further determine the potential association between the four common SNPs (rs2234693, rs9340799, rs1256049 and rs4986938) in estrogen receptors gene and male infertility, this meta-analysis was performed according to the 10 published case control studies. The odds ratio (OR) and 95% confidence interval (CI) were used to evaluate the strength of the associations. RESULTS: It was revealed that the sub-group analysis by the ethnicity, for the rs2234693, a significant association in the comparison of CC vs. TT (OR = 0.61, 95% CI: 0.40-0.93), CT vs. TT (OR = 0.67, 95% CI: 0.49-0.93) and CC + CT vs. TT (OR = 0.66, 95% CI: 0.49-0.89) in the Asian population with male infertility. For rs9340799 polymorphism, increased risks were observed for the comparison of AA vs. GG (OR = 1.75, 95% CI: 1.15-2.68) and AA vs. GA + GG (OR = 1.38, 95% CI: 1.02-1.88). For rs1256049 polymorphism, the comparison of the GA vs. GG (OR = 1.52, 95% CI: 1.00-2.31) and AA + GA vs. GG (OR = 1.74, 95% CI: 1.03-2.94), also increased risks present in Asian and Caucasian population, respectively. CONCLUSIONS: The rs2234693C allele was associated with the decreased risk for male infertility; however, the rs9340799AA genotype and the rs1256049GA genotype were associated with an increased risk for male infertility.
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Authors | Tian-Fu Li, Qiu-Yue Wu, Cui Zhang, Wei-Wei Li, Na Li, Ying-Xia Cui, Xiao-Jun Li, Xin-Yi Xia |
Journal | Reproductive biology and endocrinology : RB&E
(Reprod Biol Endocrinol)
Vol. 12
Pg. 79
(Aug 16 2014)
ISSN: 1477-7827 [Electronic] England |
PMID | 25128001
(Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't)
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Chemical References |
- ESR1 protein, human
- Estrogen Receptor alpha
- Estrogen Receptor beta
- estrogen receptor beta isoform M, human
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Topics |
- Case-Control Studies
- Estrogen Receptor alpha
(genetics, metabolism)
- Estrogen Receptor beta
(genetics, metabolism)
- Genetic Association Studies
- Genetic Predisposition to Disease
- Humans
- Infertility, Male
(genetics, metabolism)
- Male
- Polymorphism, Single Nucleotide
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