Maximum standardized uptake value on 18F-fluoro-2-deoxy-glucose positron emission tomography/computed tomography and glucose transporter-1 expression correlates with survival in invasive ductal carcinoma of the pancreas.

Abstract

OBJECTIVES:

The purpose of this study was to assess the correlations among the maximum standardized uptake value (SUVmax) on 18F-fluoro-2-deoxy-glucose positron emission tomography/computed tomography (FDG-PET/CT); the expressions of glucose transporter 1 (GLUT-1), glucose transporter 3, and epidermal growth factor receptor (EGFR); as well as prognosis in patients with invasive ductal carcinoma of the pancreas.

METHODS:

A total of 41 patients with surgically resected and histologically proven invasive ductal carcinoma of the pancreas who underwent preoperative FDG-PET/CT were assessed. The SUVmax at the primary tumor site was measured by FDG-PET/CT, and immunohistochemical staining of tumor sections was performed for GLUT-1, glucose transporter 3, and EGFR.

RESULTS:

Higher FDG uptake (SUVmax, >3.40) and GLUT-1 expression were significantly associated with shorter overall survival (P < 0.05). The SUVmax was not found to be significantly correlated with clinicopathological characteristics such as TNM classification, lymph node metastasis, and tumor differentiation. The EGFR expression was significantly correlated with the SUVmax (P = 0.024).

CONCLUSIONS:

Higher FDG uptake and GLUT-1 expression in invasive ductal carcinoma of the pancreas seems to be an important prognostic factor. In addition, the EGFR expression was significantly correlated with the SUVmax.

• Authors: Yuhei Kitasato, Masafumi Yasunaga, Koji Okuda, Hisafumi Kinoshita, Hiroyuki Tanaka, Yoshinobu Okabe, Akihiko Kawahara, Masayoshi Kage, Hayato Kaida, Masatoshi Ishibashi
• Journal: Pancreas (Pancreas) Vol. 43 Issue 7 Pg. 1060-5 (Oct 2014) ISSN: 1536-4828 [Electronic] United States
• PMID: 25121413 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Fluorine Radioisotopes
• Glucose Transporter Type 1
• Glucose Transporter Type 3
• Neoplasm Proteins
• Radiopharmaceuticals
• Fluorodeoxyglucose F18
• EGFR protein, human
• ErbB Receptors

Topics

• Adult
• Aged
• Aged, 80 and over
• Carcinoma, Pancreatic Ductal (chemistry, diagnostic imaging, mortality, surgery)
• ErbB Receptors (analysis)
• Female
• Fluorine Radioisotopes (pharmacokinetics)
• Fluorodeoxyglucose F18 (pharmacokinetics)
• Glucose Transporter Type 1 (analysis)
• Glucose Transporter Type 3 (analysis)
• Humans
• Male
• Middle Aged
• Multimodal Imaging
• Neoplasm Proteins (analysis)
• Pancreatectomy
• Pancreatic Neoplasms (chemistry, diagnostic imaging, mortality, surgery)
• Pancreaticoduodenectomy
• Positron-Emission Tomography
• Preoperative Care
• Radiopharmaceuticals (pharmacokinetics)
• Retrospective Studies
• Single-Blind Method
• Survival Analysis
• Tomography, X-Ray Computed