Abstract | BACKGROUND: AIM: To compare these therapies in terms of patient survival rates after resection and toxic effects. METHODS: We searched PubMed for controlled trials comparing the above three therapies with each other or observation alone until 31 January 2014. We estimated the hazard ratios (HRs) for death and odds ratios ( ORs) for toxic effects among different therapies. Subgroup analyses based on positive lymph node or resection margin were also performed. RESULTS: Twelve eligible articles were included. Gemcitabine improved 5-year survival (HR 2.12, 95% CI, confidence interval 1.23-4.02, P = 0.01), whereas fluorouracil (HR 1.61, 95% CI 0.74-3.67) and CRT (HR 1.55, 95% CI 0.82-3.32) provided a poorer survival outcome compared with gemcitabine after 1 year. Similarly, for 5-year survival rates, although differing, CRT did not provide a significant improvement in survival (HR 0.46, 95% CI 0.20-0.97) compared with gemcitabine. Fluorouracil did not appear to provide benefit over gemcitabine (HR 1.56, 95% CI 0.77-3.35). CRT was ranked highest for toxic effects including haematological (OR 5.45, 95% CI 0.01-483.85) and nonhaematological (OR 5.77, 95% CI 0.01-3807.40). CONCLUSIONS:
|
Authors | G-Q Zhu, K-Q Shi, J You, H Zou, Y-Q Lin, L-R Wang, M Braddock, Y-P Chen, M-H Zheng |
Journal | Alimentary pharmacology & therapeutics
(Aliment Pharmacol Ther)
Vol. 40
Issue 7
Pg. 759-70
(Oct 2014)
ISSN: 1365-2036 [Electronic] England |
PMID | 25099956
(Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't, Review, Systematic Review)
|
Copyright | © 2014 John Wiley & Sons Ltd. |
Chemical References |
- Antimetabolites, Antineoplastic
- Deoxycytidine
- Fluorouracil
- Gemcitabine
|
Topics |
- Antimetabolites, Antineoplastic
(therapeutic use)
- Biliary Tract Neoplasms
(surgery, therapy)
- Chemoradiotherapy, Adjuvant
- Deoxycytidine
(analogs & derivatives, therapeutic use)
- Fluorouracil
(therapeutic use)
- Humans
- Gemcitabine
|