Abstract | BACKGROUND: METHODS AND RESULTS:
Acrolein exposure was assessed in 211 participants of the Louisville Healthy Heart Study with moderate to high (CVD) risk by measuring the urinary levels of the major acrolein metabolite-3-hydroxypropylmercapturic acid (3-HPMA). Generalized linear models were used to assess the association between acrolein exposure and parameters of CVD risk, and adjusted for potential demographic confounders. Urinary 3-HPMA levels were higher in smokers than nonsmokers and were positively correlated with urinary cotinine levels. Urinary 3-HPMA levels were inversely related to levels of both early (AC133(+)) and late (AC133(-)) circulating angiogenic cells. In smokers as well as nonsmokers, 3-HPMA levels were positively associated with both increased levels of platelet-leukocyte aggregates and the Framingham Risk Score. No association was observed between 3-HPMA and plasma fibrinogen. Levels of C-reactive protein were associated with 3-HPMA levels in nonsmokers only. CONCLUSIONS: Regardless of its source, acrolein exposure is associated with platelet activation and suppression of circulating angiogenic cell levels, as well as increased CVD risk.
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Authors | Natasha DeJarnett, Daniel J Conklin, Daniel W Riggs, John A Myers, Timothy E O'Toole, Ihab Hamzeh, Stephen Wagner, Atul Chugh, Kenneth S Ramos, Sanjay Srivastava, Deirdre Higdon, David J Tollerud, Andrew DeFilippis, Carrie Becher, Brad Wyatt, James McCracken, Wes Abplanalp, Shesh N Rai, Tiffany Ciszewski, Zhengzhi Xie, Ray Yeager, Sumanth D Prabhu, Aruni Bhatnagar |
Journal | Journal of the American Heart Association
(J Am Heart Assoc)
Vol. 3
Issue 4
(Aug 06 2014)
ISSN: 2047-9980 [Electronic] England |
PMID | 25099132
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | © 2014 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell. |
Chemical References |
- Acrolein
- C-Reactive Protein
- S-(3-hydroxypropyl)cysteine N-acetate
- Acetylcysteine
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Topics |
- Acetylcysteine
(analogs & derivatives, urine)
- Acrolein
- Adult
- Aged
- Blood Platelets
- C-Reactive Protein
(metabolism)
- Cardiovascular Diseases
(epidemiology)
- Environmental Exposure
(statistics & numerical data)
- Female
- Humans
- Kentucky
(epidemiology)
- Leukocytes
- Linear Models
- Male
- Middle Aged
- Platelet Activation
- Smoking
(epidemiology, urine)
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