Evaluation of the anti-inflammatory and antinociceptive effects of the essential oil from leaves of Xylopia laevigata in experimental models.

Abstract

Xylopia laevigata (Annonaceae) is a medicinal plant used in folk medicine to treat pain and inflammation. Thus, we investigated the possible antioxidant, antinociceptive, and anti-inflammatory effects of X. laevigata leaf essential oil (EOX) in animal models. Our EOX sample showed the presence of γ-muurolene (17.78%), δ-cadinene (12.23%), bicyclogermacrene (7.77%), and α-copaene (7.17%) as main compounds. EOX presented a strong antioxidant potential according to the DPPH, TBARS, and nitrite production tests. Additionally, pretreatment with EOX, in mice, also significantly produced (P < 0.05 or P < 0.001) antinociceptive effect by reduction of nociceptive behavior (in formalin and writhing tests). The EOX showed c-Fos label in the olfactory bulb, piriform cortex, and periaqueductal gray. Acute administration of EOX exhibited a significant (P < 0.01 or P < 0.001) anti-inflammatory profile in the carrageenan-induced peritonitis and by the carrageenan-induced hindpaw edema tests in mice. Our results provide evidence for the use of X. laevigata by traditional medicine practitioners in the management of pain and inflammatory disorders.

• Authors: João Carlos C Queiroz, Angelo R Antoniolli, Lucindo J Quintans-Júnior, Renan G Brito, Rosana S S Barreto, Emmanoel V Costa, Thanany B da Silva, Ana Paula Nascimento Prata, Waldecy de Lucca Jr, Jackson R G S Almeida, Julianeli T Lima, Jullyana S S Quintans
• Journal: TheScientificWorldJournal (ScientificWorldJournal) Vol. 2014 Pg. 816450 ( 2014) ISSN: 1537-744X [Electronic] United States
• PMID: 25097889 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Analgesics
• Anti-Inflammatory Agents
• Oils, Volatile
• Plant Extracts
• Proto-Oncogene Proteins c-fos
• Sesquiterpenes

Topics

• Analgesics (chemistry, pharmacology, therapeutic use)
• Animals
• Anti-Inflammatory Agents (chemistry, pharmacology, therapeutic use)
• Brain (drug effects, metabolism)
• Edema (drug therapy)
• Inflammation (drug therapy)
• Male
• Mice
• Nociception (drug effects)
• Oils, Volatile (chemistry, pharmacology, therapeutic use)
• Peritonitis (drug therapy)
• Plant Extracts (chemistry, pharmacology, therapeutic use)
• Proto-Oncogene Proteins c-fos (genetics, metabolism)
• Sesquiterpenes (analysis)
• Xylopia (chemistry)