Skeletal muscle atrophy and the E3 ubiquitin ligases MuRF1 and MAFbx/atrogin-1.

Abstract

Muscle RING finger 1 (MuRF1) and muscle atrophy F-box (MAFbx)/atrogin-1 were identified more than 10 years ago as two muscle-specific E3 ubiquitin ligases that are increased transcriptionally in skeletal muscle under atrophy-inducing conditions, making them excellent markers of muscle atrophy. In the past 10 years much has been published about MuRF1 and MAFbx with respect to their mRNA expression patterns under atrophy-inducing conditions, their transcriptional regulation, and their putative substrates. However, much remains to be learned about the physiological role of both genes in the regulation of mass and other cellular functions in striated muscle. Although both MuRF1 and MAFbx are enriched in skeletal, cardiac, and smooth muscle, this review will focus on the current understanding of MuRF1 and MAFbx in skeletal muscle, highlighting the critical questions that remain to be answered.

• Authors: Sue C Bodine, Leslie M Baehr
• Journal: American journal of physiology. Endocrinology and metabolism (Am J Physiol Endocrinol Metab) Vol. 307 Issue 6 Pg. E469-84 (Sep 15 2014) ISSN: 1522-1555 [Electronic] United States
• PMID: 25096180 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Muscle Proteins
• Tripartite Motif Proteins
• FBXO32 protein, human
• Fbxo32 protein, mouse
• SKP Cullin F-Box Protein Ligases
• TRIM63 protein, human
• Trim63 protein, mouse
• Ubiquitin-Protein Ligases
• Proteasome Endopeptidase Complex

Topics

• Animals
• Gene Expression Regulation (physiology)
• Humans
• Mice
• Muscle Proteins (genetics, physiology)
• Muscle, Skeletal (metabolism, pathology)
• Muscular Atrophy (enzymology, genetics, pathology)
• Organ Size (physiology)
• Proteasome Endopeptidase Complex (metabolism)
• SKP Cullin F-Box Protein Ligases (genetics, physiology)
• Tripartite Motif Proteins
• Ubiquitin-Protein Ligases (genetics, physiology)