The CARD11-BCL10-MALT1 (CBM) signalosome complex: Stepping into the limelight of human primary immunodeficiency.

Abstract

Next-generation DNA sequencing has accelerated the genetic characterization of many human primary immunodeficiency diseases (PIDs). These discoveries can be lifesaving for the affected patients and also provide a unique opportunity to study the effect of specific genes on human immune function. In the past 18 months, a number of independent groups have begun to define novel PIDs caused by defects in the caspase recruitment domain family, member 11 (CARD11)-B-cell chronic lymphocytic leukemia/lymphoma 10 (BCL10)-mucosa-associated lymphoid tissue lymphoma translocation gene 1 (MALT1 [CBM]) signalosome complex. The CBM complex forms an essential molecular link between the triggering of cell-surface antigen receptors and nuclear factor κB activation. Germline mutations affecting the CBM complex are now recognized as the cause of novel combined immunodeficiency phenotypes, which all share abnormal nuclear factor κB activation and dysregulated B-cell development as defining features. For this "Current perspectives" article, we have engaged experts in both basic biology and clinical immunology to capture the worldwide experience in recognizing and managing patients with PIDs caused by CBM complex mutations.

• Authors: Stuart E Turvey, Anne Durandy, Alain Fischer, Shan-Yu Fung, Raif S Geha, Andreas Gewies, Thomas Giese, Johann Greil, Bärbel Keller, Margaret L McKinnon, Bénédicte Neven, Jacob Rozmus, Jürgen Ruland, Andrew L Snow, Polina Stepensky, Klaus Warnatz
• Journal: The Journal of allergy and clinical immunology (J Allergy Clin Immunol) Vol. 134 Issue 2 Pg. 276-84 (Aug 2014) ISSN: 1097-6825 [Electronic] United States
• PMID: 25087226 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2014 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.

Chemical References

• Adaptor Proteins, Signal Transducing
• B-Cell CLL-Lymphoma 10 Protein
• BCL10 protein, human
• CARD Signaling Adaptor Proteins
• NF-kappa B
• Neoplasm Proteins
• Receptors, Antigen, B-Cell
• Caspases
• MALT1 protein, human
• Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein
• CARD11 protein, human
• Guanylate Cyclase

Topics

• Adaptor Proteins, Signal Transducing (genetics, immunology)
• B-Cell CLL-Lymphoma 10 Protein
• B-Lymphocytes (immunology, pathology)
• CARD Signaling Adaptor Proteins (genetics, immunology)
• Caspases (genetics, immunology)
• Gene Expression Regulation
• Germ-Line Mutation
• Guanylate Cyclase (genetics, immunology)
• High-Throughput Nucleotide Sequencing
• Humans
• Immunologic Deficiency Syndromes (diagnosis, genetics, immunology, pathology)
• Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein
• NF-kappa B (genetics, immunology)
• Neoplasm Proteins (genetics, immunology)
• Receptors, Antigen, B-Cell (genetics, immunology)
• Signal Transduction