Abstract |
Severe cyclical dehydration induces chronic renal injury in rodents. This effect is attenuated by global fructokinase deficiency, suggesting possible roles for fructokinase and fructose metabolism in mediating or promoting dehydration-induced injury. Clinical and pathological similarities between this injury model and endemic Mesoamerican nephropathy (MeN) have fueled speculation that dehydration-induced injury and MeN may share common mechanistic underpinnings involving fructokinase that can be targeted to mitigate disease development, progression, and/or severity.
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Authors | R Brooks Robey |
Journal | Kidney international
(Kidney Int)
Vol. 86
Issue 2
Pg. 226-9
(Aug 2014)
ISSN: 1523-1755 [Electronic] United States |
PMID | 25079017
(Publication Type: Journal Article, Comment)
|
Chemical References |
- Fructokinases
- ketohexokinase
|
Topics |
- Animals
- Dehydration
(enzymology)
- Fructokinases
(metabolism)
- Kidney
(injuries)
- Male
|