Abstract | PURPOSE: METHODS: A total of 60 girls with central precocious puberty ( CPP) and 30 control girls were enrolled. Anthropometric measurement and serum level of 25OHD were estimated for all subjects. RESULTS: There was a significant difference in the mean serum 25OHD concentration between the precocious puberty group and the control group (17.1±4.5 ng/mL vs. 21.2±5.0 ng/mL, P<0.05). Forty-two of the 60 girls with CPP (70%) had vitamin D deficiency (defined as serum 25OHD<20 ng/mL) and 18 (30%) had vitamin D insufficiency. Of the 30 girls in the control group, vitamin D deficiency was seen in 13 subjects (43.3%), 15 subjects (50%) had vitamin D insufficiency, and 2 subjects (6.7%) had sufficient serum vitamin D (defined as serum 25OHD>30 ng/mL). Vitamin D deficient girls had a significantly higher odds ratio (OR, 3.05; 95% CI, 1.22-7.57, P=0.021). CONCLUSION: These results showed that vitamin D levels may be associated with precocious puberty. Further studies are required to establish the potential effect of vitamin D status on puberty.
|
Authors | Hae Sang Lee, You Jin Kim, Young Seok Shim, Hwal Rim Jeong, Eunbyul Kwon, Jin Soon Hwang |
Journal | Annals of pediatric endocrinology & metabolism
(Ann Pediatr Endocrinol Metab)
Vol. 19
Issue 2
Pg. 91-5
(Jun 2014)
ISSN: 2287-1012 [Print] Korea (South) |
PMID | 25077092
(Publication Type: Journal Article)
|