The effect of drospirenone (3 mg) with ethinyl estradiol (30 mcg) containing pills on ovarian blood flows in women with polycystic ovary syndrome: a case controlled study.

Abstract

OBJECTIVE:

To evaluate whether oral contraceptive pill (OCP) therapy has any effects on ovarian stromal blood flow by using pulsed and color Doppler at the end of 3 months follow-up period of OCP-users and non-users with or without polycystic ovary syndrome (PCOS).

STUDY DESIGN:

200 patients were included in the study. The patients were designed into four groups as follows; Group 1: PCOS patients that received OCP containing 30 mcg ethinyl estradiol (EE) plus 3mg drospirenone for 3 months (DRP n=50); Group 2: PCOS patients that received no medication (n=50); Group 3: Healthy controls that received OCP (EE plus DRP) (n=50); Group 4: healthy controls that received no medication (n=50). Resistance index (RI) and pulsatility index (PI) of both ovarian arteries, hormonal, anthropometric and biochemical parameters were assessed before and after 3 months.

RESULTS:

There was a significant increament in RI and PI of both ovarian arteries in healthy controls (Group 3) and in women with PCOS (Group 1) who received OCP (p<0.001). The increment rate in both Doppler parameters were significantly higher in women with PCOS (Group 1) than healthy controls (Group 3) (p<0.001). Whereas RI and PI values of both ovaries remained unchanged in all untreated women with or without PCOS (Groups 2 and 4).

CONCLUSION:

OCP therapy reduced ovarian vascularization in both PCOS and healthy users after 3 months of therapy and this decrease is especially noticeable in women with PCOS.

• Authors: Emre Okyay, Funda Gode, Ferruh Acet, Taylan Bodur, Erkan Cagliyan, Ceyda Sahan, Cemal Posaci, Bulent Gulekli
• Journal: European journal of obstetrics, gynecology, and reproductive biology (Eur J Obstet Gynecol Reprod Biol) Vol. 180 Pg. 93-9 (Sep 2014) ISSN: 1872-7654 [Electronic] Ireland
• PMID: 25063905 (Publication Type: Journal Article)
• Copyright: Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• Androstenes
• Contraceptives, Oral, Combined
• drospirenone and ethinyl estradiol combination
• Ethinyl Estradiol

Topics

• Adult
• Androstenes (pharmacology)
• Case-Control Studies
• Contraceptives, Oral, Combined (pharmacology)
• Ethinyl Estradiol (pharmacology)
• Female
• Humans
• Ovary (blood supply, diagnostic imaging)
• Polycystic Ovary Syndrome (blood supply, diagnostic imaging, drug therapy)
• Prospective Studies
• Regional Blood Flow (drug effects)
• Ultrasonography, Doppler, Color
• Ultrasonography, Doppler, Pulsed
• Young Adult