Abstract | BACKGROUND: OBJECTIVE: In this long-term naturalistic study, we evaluated the effectiveness of cognitive enhancers in patients with mixed AD with svCVD. METHODS: We conducted a retrospective analysis of a prospective clinical database from a memory clinic of a tertiary hospital. Magnetic resonance imaging WMH was used as a marker of svCVD. Demographic, cognitive, and treatment data were analysed. Linear mixed models with patient-specific random effects were used to evaluate cognitive outcomes over time while adjusting for confounders. RESULTS: Patients with mixed AD (n = 137) or AD without svCVD (pure AD) (n = 28) were studied over a median duration of 28.7 months. Patients with mixed AD had a higher prevalence of hypertension (62.8 vs. 35.7 %, p = 0.011). The majority (75.2 %) of the study sample were managed with monotherapy. Mini Mental State Examination (MMSE) scores decreased over time (-0.04, p = 0.007), and the decrease was similar for both diagnosis groups (-0.03, p = 0.246). Annual estimated mean MMSE decline was 0.84 for pure AD and 0.48 for mixed AD. Similar trends were observed with Montreal Cognitive Assessment (MoCA) scores, with annual estimated mean reduction of 0.72 and 0.48 for pure AD and mixed AD, respectively. CONCLUSION:
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Authors | Kok Pin Ng, Aloysius Ng, Pryseley Assam, Esther Heng, Nagaendran Kandiah |
Journal | Drugs in R&D
(Drugs R D)
Vol. 14
Issue 3
Pg. 195-203
(Sep 2014)
ISSN: 1179-6901 [Electronic] New Zealand |
PMID | 25063270
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Aged
- Aged, 80 and over
- Alzheimer Disease
(drug therapy, physiopathology)
- Cerebrovascular Disorders
(drug therapy, etiology)
- Cognition Disorders
(drug therapy, etiology)
- Databases, Factual
- Female
- Follow-Up Studies
- Humans
- Hypertension
(epidemiology)
- Magnetic Resonance Imaging
- Male
- Middle Aged
- Nootropic Agents
(pharmacology)
- Retrospective Studies
- Time Factors
- White Matter
(pathology)
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