Sarcoma response to targeted therapy dynamically polarizes tumor-associated macrophages.

Abstract

In gastrointestinal stromal tumor (GIST), the most common human sarcoma, tumor-associated macrophages (TAMs) have been found to be abundant and surprisingly M1-like, exhibiting antitumoral activities. However, TAMs switch to M2-like during the course of imatinib therapy, but upon drug resistance TAMs revert to M1-like. Therefore, the oncologic efficacy of TAM depletion may depend on tumor type and treatment status.

• Authors: Michael J Cavnar, Ronald P DeMatteo
• Journal: Oncoimmunology (Oncoimmunology) 2014 Vol. 3 Pg. e28463 ISSN: 2162-4011 [Print] United States
• PMID: 25050212 (Publication Type: Journal Article)