Among the 3020 participants, the prevalence of
diabetes mellitus was 37% with a mean duration of 11 years.
Diabetes mellitus was independently associated with slightly younger age (63 versus 64 years; P<0.001), Hispanic ethnicity (36% versus 28%; P<0.0001),
ischemic heart disease (11% versus 6%; P=0.002), and
peripheral vascular disease (5% versus 2%; P<0.001). Patients with
diabetes mellitus more frequently had intracranial
stenosis ≥50% (P<0.001),
infarcts involving the brain stem or cerebellum (P<0.001), and more extensive white matter abnormalities (P<0.001). Patients with
diabetes mellitus were almost twice as likely to have a recurrent
stroke (hazard ratio [HR], 1.8; 95% confidence interval [CI], 1.4-2.3), recurrent
ischemic stroke (HR, 1.8; 95% CI, 1.4-2.4), disabling/fatal
stroke (HR, 1.8; 95% CI, 1.2-2.9),
myocardial infarction (HR, 1.7; 95% CI, 1.0-2.8), and death (HR, 2.1 95% CI, 1.6-2.8) compared with patients without
diabetes mellitus.
CONCLUSIONS: http://www.clinicaltrials.gov. Unique identifier: NCT00059306.