Abstract | BACKGROUND: OBJECTIVE: STUDY DESIGN: The conserved N-terminal portion of the measles nucleocapsid protein (NCORE) was expressed as a specific antigen devoid of human or primate components. Serological analyses were performed on CSF and sera from MS patients, their clinically healthy siblings and healthy unrelated controls. RESULTS: MS patients demonstrated higher IgG reactivity compared to healthy controls in both CSF (P<0.001) and serum (P<0.001), and compared to siblings in CSF (P<0.001) and serum (P=0.2). Siblings with MS OCB trait showed higher IgG reactivity than healthy controls in CSF (P=0.002) and serum (P=0.01). Comparison between siblings with MS OCB trait and siblings without MS OCB trait showed (P=0.04) for CSF and (P=0.08) for serum. CONCLUSION: These findings suggest a measles-specific component in the antibody reactivity demonstrated by MS patients and their siblings with the MS OCB trait.
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Authors | Linn Persson, Sonia Longhi, Johanna Enarsson, Oluf Andersen, Sara Haghigi, Staffan Nilsson, Martin Lagging, Maria Johansson, Tomas Bergström |
Journal | Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
(J Clin Virol)
Vol. 61
Issue 1
Pg. 107-12
(Sep 2014)
ISSN: 1873-5967 [Electronic] Netherlands |
PMID | 25022622
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2014 Elsevier B.V. All rights reserved. |
Chemical References |
- Antibodies, Viral
- Immunoglobulin G
- Nucleocapsid Proteins
- Oligoclonal Bands
- measles virus nucleocapsid protein
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Topics |
- Adolescent
- Adult
- Aged
- Animals
- Antibodies, Viral
(blood)
- Cohort Studies
- Female
- Humans
- Immunoglobulin G
(blood, cerebrospinal fluid)
- Male
- Middle Aged
- Multiple Sclerosis
(immunology, pathology)
- Nucleocapsid Proteins
(immunology)
- Oligoclonal Bands
(blood, cerebrospinal fluid)
- Siblings
- Young Adult
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