Biomarker progressions explain higher variability in stage-specific cognitive decline than baseline values in Alzheimer disease.

Abstract

BACKGROUND:

It is unknown which commonly used Alzheimer disease (AD) biomarker values-baseline or progression-best predict longitudinal cognitive decline.

METHODS:

526 subjects from the Alzheimer's Disease Neuroimaging Initiative (ADNI). ADNI composite memory and executive scores were the primary outcomes. Individual-specific slope of the longitudinal trajectory of each biomarker was first estimated. These estimates and observed baseline biomarker values were used as predictors of cognitive declines. Variability in cognitive declines explained by baseline biomarker values was compared with variability explained by biomarker progression values.

RESULTS:

About 40% of variability in memory and executive function declines was explained by ventricular volume progression among mild cognitive impairment patients. A total of 84% of memory and 65% of executive function declines were explained by fluorodeoxyglucose positron emission tomography (FDG-PET) score progression and ventricular volume progression, respectively, among AD patients.

CONCLUSIONS:

For most biomarkers, biomarker progressions explained higher variability in cognitive decline than biomarker baseline values. This has important implications for clinical trials targeted to modify AD biomarkers.

• Authors: Hiroko H Dodge, Jian Zhu, Danielle Harvey, Naomi Saito, Lisa C Silbert, Jeffrey A Kaye, Robert A Koeppe, Roger L Albin, Alzheimer's Disease Neuroimaging Initiative
• Journal: Alzheimer's & dementia : the journal of the Alzheimer's Association (Alzheimers Dement) Vol. 10 Issue 6 Pg. 690-703 (Nov 2014) ISSN: 1552-5279 [Electronic] United States
• PMID: 25022534 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2014 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

Chemical References

• Biomarkers
• Fluorodeoxyglucose F18

Topics

• Aged
• Aged, 80 and over
• Alzheimer Disease (complications, diagnostic imaging)
• Biomarkers (metabolism)
• Cognition Disorders (diagnosis, etiology)
• Databases, Factual (statistics & numerical data)
• Disease Progression
• Executive Function
• Female
• Fluorodeoxyglucose F18
• Humans
• Longitudinal Studies
• Magnetic Resonance Imaging
• Male
• Memory
• Mental Status Schedule
• Neuropsychological Tests
• Positron-Emission Tomography