A phase 1b study of trebananib in combination with pegylated liposomal doxorubicin or topotecan in women with recurrent platinum-resistant or partially platinum-sensitive ovarian cancer.

Abstract

OBJECTIVE:

To examine the tolerability and antitumor activity of trebananib plus pegylated liposomal doxorubicin (PLD) or topotecan in recurrent platinum-resistant or partially platinum-sensitive ovarian cancer.

METHODS:

In this open-label phase 1b study, patients received trebananib 10 mg/kg or 15 mg/kg IV QW plus PLD 50 mg/m(2) (cohorts A1 and A3, respectively) or topotecan 4 mg/m(2) (cohorts B1 and B3, respectively). Endpoints were dose-limiting toxicity (DLT; primary); treatment-emergent adverse events (AEs), overall response rate, anti-trebananib antibodies, and pharmacokinetics (secondary).

RESULTS:

103 patients were enrolled. One patient in A1 and B1 had DLTs. Across all cohorts, the most common AEs were nausea, fatigue, and peripheral edema. Across both trebananib plus PLD cohorts (A1/A3), grade 4 AEs were pulmonary embolism, disease progression, and anemia. Two patients had grade 5 intestinal perforation (n=1) and sudden death (n=1). Across both trebananib plus topotecan cohorts (B1/B3), grade 4 AEs were neutropenia, hypokalemia, decreased granulocyte count, chest pain, dyspnea, decreased neutrophil count, and pulmonary embolism. Two patients had grade 5 disease progression. One patient had grade 5 pleural effusion associated with progressive disease. Confirmed objective response rates were 36.0% (A1), 34.8% (A3), 16.7% (B1), and 0.0% (B3). Median progression-free survival duration (months) was 7.4 (A1), 7.1 (A3), 3.5 (B1), and 3.1 (B3), respectively. No drug-drug interactions were apparent.

CONCLUSIONS:

Trebananib 10mg/kg and 15 mg/kg IV QW plus PLD or topotecan appear to have acceptable toxicity profiles in recurrent platinum-resistant or partially platinum-sensitive ovarian cancer. Antitumor activity was evident across all cohorts.

• Authors: Ignace Vergote, Russell J Schilder, Charles H Pippitt Jr, Shirley Wong, Alan N Gordon, Sidney Scudder, Frederic Kridelka, Luc Dirix, Joseph W Leach, Sumitra Ananda, Nuwan Nanayakkara, Rebeca Melara, Michael B Bass, Jason Litten, Henry Adewoye, Robert M Wenham
• Journal: Gynecologic oncology (Gynecol Oncol) Vol. 135 Issue 1 Pg. 25-33 (Oct 2014) ISSN: 1095-6859 [Electronic] United States
• PMID: 25019569 (Publication Type: Clinical Trial, Phase I, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2014 Elsevier Inc. All rights reserved.

Chemical References

• Angiogenesis Inhibitors
• Antibiotics, Antineoplastic
• Platinum Compounds
• Recombinant Fusion Proteins
• Topoisomerase I Inhibitors
• liposomal doxorubicin
• Polyethylene Glycols
• Topotecan
• Doxorubicin
• trebananib

Topics

• Adult
• Aged
• Aged, 80 and over
• Angiogenesis Inhibitors (administration & dosage, adverse effects)
• Antibiotics, Antineoplastic (administration & dosage, adverse effects)
• Doxorubicin (administration & dosage, adverse effects, analogs & derivatives)
• Drug Resistance, Neoplasm
• Drug Therapy, Combination
• Female
• Humans
• Middle Aged
• Neoplasm Recurrence, Local (drug therapy)
• Ovarian Neoplasms (drug therapy)
• Platinum Compounds (adverse effects, therapeutic use)
• Polyethylene Glycols (administration & dosage, adverse effects)
• Recombinant Fusion Proteins (administration & dosage, adverse effects)
• Topoisomerase I Inhibitors (administration & dosage, adverse effects)
• Topotecan (administration & dosage, adverse effects)