We conducted a case-control study to investigate the role of three common
IL-17A and
IL-17F single nucleotide polymorphisms (SNPs) on the susceptibility to
gastric cancer. A case-control study was conducted using a Chinese study population of 462
gastric cancer subjects and 462 controls. Polymerase chain reaction restriction fragment length of polymorphism (PCR-RFLP) was taken to genotype rs2275913, rs763780, and rs3748067 within the
IL-17 gene. When comparing demographic characteristics of
gastric cancer between
gastric cancer cases and control groups,
cancer cases were more likely to be cigarette smokers and alcohol drinkers, have
cancer history in the first relatives, and have higher
infection rate of Helicobacter pylori. By conditional regression analysis, individuals carrying
IL-17 rs2275913 GA, AA genotype, and A allele were associated with an increased
gastric cancer risk. Those carrying rs3748067 CC genotype and C allele had a significantly increased risk for the development of
gastric cancer. Moreover, rs2275913 and rs3748067 variations had association with cigarette smoking, alcohol drinking, and H. pylori
infection on the risk of
gastric cancer. These results suggest that rs2275913 and rs3748067 variations significantly increase
gastric cancer risk in a Chinese population.