Effects of a novel therapeutic diet on liver enzymes and coagulating factors in patients with non-alcoholic fatty liver disease: A parallel randomized trial.

Abstract

OBJECTIVE:

There are several reports regarding the role of therapeutic diets for patients with non-alcoholic fatty liver disease (NAFLD). Therefore, the aim of this study was to determine the effects of a low-calorie, low-carbohydrate soy-containing diet on lipid profiles, liver enzymes, and coagulating factors in patients with NAFLD.

METHOD:

This was a randomized parallel clinical trial involving 45 patients with NAFLD. The participants consumed three kinds of diets for 8 wk. Patients were randomly assigned to consume a low-calorie diet; a low-calorie, low-carbohydrate diet; or a low-calorie, low-carbohydrate soy-containing diet. Measurements were done according to the standard method.

RESULTS:

Changes in weight were not significantly different in the three groups. The low-calorie, low-carbohydrate soy-containing diet could reduce alanine aminotransferase (-15.2 ± 12.1 versus -6.8 ± 4.6 in the low-calorie, low-carbohydrate diet, and -6.4 ± 4.4 IU/L in the low-calorie diet; P = 0.02) and serum fibrinogen levels (-49.1 ± 60.1 versus -12.9 ± 8.1 and -17.4 ± 8.4 g/L, respectively; P = 0.01). Reductions in aspartate aminotransferase were significantly higher in the low-calorie, low-carbohydrate soy-containing group. Changes in lipid profiles did not differ significantly between the groups. The soy-containing diet did reduce malondialdehyde more than the other diets (P = 0.01).

CONCLUSION:

A low-calorie, low-carbohydrate soy-containing diet could have beneficial effects on liver enzymes, malondialdehyde, and serum fibrinogen levels in patients with NAFLD.

• Authors: Ali Hashemi Kani, Seyed Moayed Alavian, Ahmad Esmaillzadeh, Peyman Adibi, Leila Azadbakht
• Journal: Nutrition (Burbank, Los Angeles County, Calif.) (Nutrition) 2014 Jul-Aug Vol. 30 Issue 7-8 Pg. 814-21 ISSN: 1873-1244 [Electronic] United States
• PMID: 24984998 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2014 Elsevier Inc. All rights reserved.

Chemical References

• Lipids
• Malondialdehyde
• Fibrinogen
• Alanine Transaminase

Topics

• Adult
• Alanine Transaminase (blood)
• Body Weight (drug effects)
• Caloric Restriction
• Diet, Carbohydrate-Restricted
• Diet, Reducing
• Energy Intake
• Female
• Fibrinogen (metabolism)
• Humans
• Lipids (blood)
• Liver (drug effects, enzymology)
• Male
• Malondialdehyde (blood)
• Middle Aged
• Non-alcoholic Fatty Liver Disease (blood, diet therapy)
• Obesity (complications, diet therapy)
• Seeds
• Glycine max