Stroke mortality associated with environmental tobacco smoke among never-smoking Japanese women: a prospective cohort study.

Abstract

OBJECTIVE:

This study examined the association of exposure to environmental tobacco smoke (ETS) during adulthood with stroke and its subtypes using data from a large-scale prospective cohort study in Japan.

METHODS:

The study population included 36,021 never-smoking Japanese women who were enrolled between 1983 and 1985 and were followed-up for 15 years. We used Cox proportional hazard regression models to estimate hazard ratios (HRs) for stroke death associated with ETS exposure at home during adulthood.

RESULTS:

A total of 906 cases of stroke death were observed during 437,715 person-years of follow-up. Compared with never-smoking women without smoking family members, HRs for stroke mortality among never-smoking women living with smoking family members in all subjects, in those aged 40-79 years, and in those aged ≥ 80 years were 1.14 (95% confidence interval: 0.99-1.31), 1.24 (95% CI: 1.05-1.46), and 0.89 (95% CI: 0.66-1.19), respectively, after adjustment for possible confounders. The risk was most evident for subarachnoid hemorrhage [HR: 1.66 (95% CI: 1.02-2.70) in all subjects].

CONCLUSION:

This study suggests that exposure to ETS at home during adulthood is associated with an increased risk of stroke among never-smoking Japanese women.

• Authors: Yoshikazu Nishino, Ichiro Tsuji, Hideo Tanaka, Tomio Nakayama, Haruo Nakatsuka, Hidemi Ito, Takaichiro Suzuki, Kota Katanoda, Tomotaka Sobue, Suketami Tominaga, Three-Prefecture Cohort Study Group
• Journal: Preventive medicine (Prev Med) Vol. 67 Pg. 41-5 (Oct 2014) ISSN: 1096-0260 [Electronic] United States
• PMID: 24983889 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2014 Elsevier Inc. All rights reserved.

Chemical References

• Tobacco Smoke Pollution

Topics

• Adult
• Aged
• Aged, 80 and over
• Cohort Studies
• Environmental Exposure (adverse effects)
• Female
• Humans
• Japan (epidemiology)
• Middle Aged
• Prospective Studies
• Risk Assessment
• Smoking (epidemiology)
• Stroke (epidemiology, mortality)
• Tobacco Smoke Pollution (adverse effects)