Abstract | PURPOSE: METHODS: Twenty-eight patients with pathologically confirmed stage I-IV ESCC and who received definitive CCRT were prospectively enrolled into this trial. The (18)F-FDG PET/CT scans were performed four times. The maximum standardized uptake values (SUVmax) of each scanning were named as SUVmaxpet1, SUVmaxpet2, SUVmaxpet3, and SUVmaxpet4, respectively. The tumor volume with SUV greater than 40% of SUVmax was named as metabolic tumor volume (MTV). Follow-up investigation of patients was performed to record progression-free survival (PFS), relapse-free survival (RFS), and overall survival time (OS). RESULTS: The average value of MTV before treatment is 19.3 ml. The average value of SUVmax at four time points was 13.0 ± 7.4, 6.4 ± 3.2, 4.7 ± 1.9, and 3.4 ±1.8, respectively. Median follow-up time was 18.5 months (range 5-40). There was statistically significant difference in ΔR14 ((SUVmaxpet1- SUVmaxpet4) / SUVmaxpet1). Multivariate Cox regression survival analysis indicated that the MTV was an independent prognostic factor for PFS and RFS (HR = 1.13 and 1.14, respectively) before treatment. CONCLUSION: In CCRT of non-surgical ESCC, MTV before treatment could independently predict OS survival. SUVmaxpet2, SUVmaxpet3, and SUVmaxpet4 could predict RFS. Patients with reductions of SUVmaxpet4 less than 75% had a poor PFS, RFS, and OS.
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Authors | Yimin Li, Qin Lin, Lichen Wang, Long Sun, Mingming Dai, Zuoming Luo, Hua Zheng, Long Zhao, Hua Wu |
Journal | Journal of B.U.ON. : official journal of the Balkan Union of Oncology
(J BUON)
2014 Apr-Jun
Vol. 19
Issue 2
Pg. 517-23
ISSN: 1107-0625 [Print] Cyprus |
PMID | 24965415
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Radiopharmaceuticals
- Fluorodeoxyglucose F18
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Topics |
- Aged
- Aged, 80 and over
- Carcinoma, Squamous Cell
(diagnostic imaging, mortality, therapy)
- Chemoradiotherapy
- Esophageal Neoplasms
(diagnostic imaging, mortality, therapy)
- Esophageal Squamous Cell Carcinoma
- Female
- Fluorodeoxyglucose F18
- Humans
- Male
- Middle Aged
- Positron-Emission Tomography
(methods)
- Proportional Hazards Models
- Radiopharmaceuticals
- Tomography, X-Ray Computed
(methods)
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