Changes in capsule and drug resistance of Pneumococci after introduction of PCV7, Japan, 2010-2013.

Abstract

We aimed to clarify changes in serotypes and genotypes mediating β-lactam and macrolide resistance in Streptococcus pneumoniae isolates from Japanese children who had invasive pneumococcal disease (IPD) after the 7-valent pneumococcal conjugate vaccine (PCV7) was introduced into Japan; 341 participating general hospitals conducted IPD surveillance during April 2010-March 2013. A total of 300 pneumococcal isolates were collected in 2010, 146 in 2011, and 156 in 2012. The proportion of vaccine serotypes in infectious isolates decreased from 73.3% to 54.8% to 14.7% during the 3 years. Among vaccine serotype strains, genotypic penicillin-resistant S. pneumoniae strains also declined each year. Among nonvaccine serotype strains, 19A, 15A, 15B, 15C, and 24 increased in 2012. Increases were noted especially in genotypic penicillin-resistant S. pneumoniae isolates of serotypes 15A and 35B, as well as macrolide resistance mediated by the erm(B) gene in 15A, 15B, 15C, and 24.

• Authors: Naoko Chiba, Miyuki Morozumi, Michi Shouji, Takeaki Wajima, Satoshi Iwata, Kimiko Ubukata, Invasive Pneumococcal Diseases Surveillance Study Group
• Journal: Emerging infectious diseases (Emerg Infect Dis) Vol. 20 Issue 7 Pg. 1132-9 (Jul 2014) ISSN: 1080-6059 [Electronic] United States
• PMID: 24960150 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Bacterial Agents
• Heptavalent Pneumococcal Conjugate Vaccine
• Macrolides
• Penicillins
• Pneumococcal Vaccines

Topics

• Anti-Bacterial Agents (therapeutic use)
• Child
• Child, Preschool
• Drug Resistance, Bacterial (drug effects, genetics, immunology)
• Genotype
• Heptavalent Pneumococcal Conjugate Vaccine
• Humans
• Infant
• Japan
• Macrolides (therapeutic use)
• Penicillins (therapeutic use)
• Pneumococcal Infections (drug therapy, immunology, microbiology)
• Pneumococcal Vaccines (immunology)
• Serotyping
• Streptococcus pneumoniae (classification, drug effects, genetics, immunology)
• beta-Lactam Resistance (genetics, immunology)