Abstract | BACKGROUND AND PURPOSE: MATERIALS AND METHODS: Podoplanin expression (≤10 % versus > 10 %) and 12 other factors were evaluated in 160 patients for their association with locoregional control (LRC), metastases-free (MFS) and overall survival (OS). Other factors were age, gender, Eastern Cooperative Oncology Group (ECOG) performance status, preradiotherapy (pre-RT) hemoglobin level, tumor site, histological grading, T category, N category, American Joint Committee on Cancer (AJCC) stage, human papillomavirus (HPV) status, extent of resection and concurrent chemotherapy. RESULTS: In multivariate analysis, ECOG performance status 0-1 (risk ratio, RR: 3.01; 95 % confidence interval, CI: 1.42-7.14; p = 0.003), pre-RT hemoglobin levels ≥ 7.45 mmol/l (12 g/dl; RR: 2.03; 95 % CI: 1.04-3.94; p = 0.038), oropharyngeal cancer (RR: 1.25; 95 % CI: 1.01-1.55; p = 0.038) and T category T1-2 (RR: 1.81; 95 % CI: 1.24-2.79; p = 0.002) were significantly associated with improved LRC. T category T1-2 (RR: 1.90; 95 % CI: 1.25-3.06; p = 0.002) and N category N0-2a (RR: 5.22; 95 % CI: 1.96-18.09; p < 0.001) were significantly associated with better MFS. Pre-RT hemoglobin levels ≥ 7.45 mmol/l (RR: 2.44; 95 % CI: 1.27-4.74; p = 0.007), T category T1-2 (RR: 1.97; 95 % CI: 1.36-3.04; p < 0.001) and N category N0-2a (RR: 2.87; 95 % CI: 1.37-6.61; p = 0.005) were significantly associated with improved OS. Podoplanin expression ≤ 10 % showed a trend towards improved OS on both univariate (p = 0.050) and multivariate analysis (RR: 1.86; 95 % CI: 0.96-3.59; p = 0.07). CONCLUSION: Treatment outcomes were significantly associated with performance status, pre-RT hemoglobin level, tumor site and tumor stage. Tumor cell expression of podoplanin ≤ 10 % showed a trend towards improved OS when compared to podoplanin expression of > 10 %.
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Authors | Stefan Huttenlocher, Nina D Seibold, Maximilian P Gebhard, Frank Noack, Christoph Thorns, Katrin Hasselbacher, Barbara Wollenberg, Steven E Schild, Dirk Rades |
Journal | Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]
(Strahlenther Onkol)
Vol. 190
Issue 11
Pg. 1021-7
(Oct 2014)
ISSN: 1439-099X [Electronic] Germany |
PMID | 24928249
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers, Tumor
- Membrane Glycoproteins
- PDPN protein, human
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Biomarkers, Tumor
(metabolism)
- Carcinoma, Squamous Cell
(diagnosis, mortality, radiotherapy)
- Female
- Germany
(epidemiology)
- Head and Neck Neoplasms
(diagnosis, mortality, radiotherapy)
- Humans
- Male
- Membrane Glycoproteins
(metabolism)
- Middle Aged
- Neoplasm Recurrence, Local
(metabolism, mortality, prevention & control)
- Prevalence
- Prognosis
- Reproducibility of Results
- Risk Factors
- Sensitivity and Specificity
- Squamous Cell Carcinoma of Head and Neck
- Survival Rate
- Treatment Outcome
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