Analysis of gastrin-releasing peptide gene and gastrin-releasing peptide receptor gene in patients with agoraphobia.

Abstract

A gastrin-releasing peptide receptor (GRPR) knock-out mouse model provided evidence that the gastrin-releasing peptide (GRP) and its neural circuitry operate as a negative feedback-loop regulating fear, suggesting a novel candidate mechanism contributing to individual differences in fear-conditioning and associated psychiatric disorders such as agoraphobia with/without panic disorder. Studies in humans, however, provided inconclusive evidence on the association of GRP and GRPR variations in agoraphobia with/without panic disorder. Based on these findings, we investigated whether GRP and GRPR variants are associated with agoraphobia. Mental disorders were assessed via the Munich-Composite International Diagnostic Interview (M-CIDI) in 95 patients with agoraphobia with/without panic disorder and 119 controls without any mental disorders. A complete sequence analysis of GRP and GRPR was performed in all participants. We found no association of 16 GRP and 7 GRPR variants with agoraphobia with/without panic disorder.

• Authors: Katrin Zimmermann, Heike Görgens, David Bräuer, Franziska Einsle, Barbara Noack, Stephanie von Kannen, Maria Grossmann, Jürgen Hoyer, Alexander Strobel, Volker Köllner, Kerstin Weidner, Andreas Ziegler, Claudia Hemmelmann, Hans K Schackert
• Journal: Psychiatric genetics (Psychiatr Genet) Vol. 24 Issue 5 Pg. 232-3 (Oct 2014) ISSN: 1473-5873 [Electronic] England
• PMID: 24912045 (Publication Type: Letter)

Chemical References

• Receptors, Bombesin
• Gastrin-Releasing Peptide

Topics

• Agoraphobia (genetics)
• Case-Control Studies
• Gastrin-Releasing Peptide (genetics)
• Genetic Predisposition to Disease
• Humans
• Receptors, Bombesin (genetics)