Abstract | BACKGROUND: The key determinants of daytime drowsiness in sleep disordered breathing (SDB) are unclear. Hypercapnia has not been examined as a potential contributor due to the lack of reliable measurement during sleep. To overcome this limitation, we studied predominantly hypercapnic SDB patients to investigate the role of hypercapnia on EEG activation and daytime sleepiness. METHODS: RESULTS: After the PAP treatment, these patients showed a significant decrease in their waking pCO(2), daytime sleepiness, as well as all key breathing/oxygenation parameters during sleep. Overnight Delta/Alpha ratio of EEG was significantly reduced. There is a significant cross-correlation between a reduced wake pCO(2), a faster (more activated) sleep EEG (reduced Delta/Alpha ratio) and reduced daytime sleepiness (all p < 0.05) with PAP treatment. Multiple regression analyses showed the degree of change in hypercapnia to be the only significant predictor for both ESS and Delta/ Alpha ratio. CONCLUSIONS:
|
Authors | David Wang, Amanda J Piper, Brendon J Yee, Keith K Wong, Jong-Won Kim, Angela D'Rozario, Luke Rowsell, Derk-Jan Dijk, Ronald R Grunstein |
Journal | Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine
(J Clin Sleep Med)
Vol. 10
Issue 5
Pg. 517-22
(May 15 2014)
ISSN: 1550-9397 [Electronic] United States |
PMID | 24910553
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Topics |
- Brain
(physiopathology)
- Disorders of Excessive Somnolence
(etiology, physiopathology)
- Electroencephalography
- Female
- Humans
- Hypercapnia
(etiology, physiopathology)
- Male
- Middle Aged
- Polysomnography
- Sleep Apnea Syndromes
(complications, physiopathology)
|