Efficacy of Malarone(®) in dogs naturally infected with Babesia gibsoni.

Abstract

The efficacy of Malarone(®) alone and in combination with doxycycline (DOXY) against Babesia gibsoni infections was examined in 8 dogs. In all dogs except one treated with Malarone(®), parasitemia decreased, and anemia improved soon after initiation of treatment. However, 3 of 4 dogs treated with Malarone(®) relapsed, and relapse was inhibited in 2 of 4 dogs treated with Malarone(®) and DOXY. All relapsed dogs responded well to the second treatment, but 1 dog relapsed again and did not respond to the third treatment. Malarone(®) may be useful for acute stage of B. gibsoni infections, and at least second repeating treatment might be effective.

• Authors: Aiko Iguchi, Nobuyuki Shiranaga, Aya Matsuu, Yoshiaki Hikasa
• Journal: The Journal of veterinary medical science (J Vet Med Sci) Vol. 76 Issue 9 Pg. 1291-5 (Sep 2014) ISSN: 1347-7439 [Electronic] Japan
• PMID: 24909969 (Publication Type: Journal Article)

Chemical References

• DNA, Protozoan
• Drug Combinations
• Globulins
• Serum Albumin
• atovaquone, proguanil drug combination
• Creatinine
• Alanine Transaminase
• Alkaline Phosphatase
• Doxycycline
• Bilirubin
• Proguanil
• Atovaquone

Topics

• Alanine Transaminase (blood)
• Alkaline Phosphatase (blood)
• Animals
• Atovaquone (administration & dosage, pharmacology, therapeutic use)
• Babesia (growth & development)
• Babesiosis (drug therapy, parasitology)
• Bilirubin (analysis)
• Blood Cell Count (veterinary)
• Blood Urea Nitrogen
• Creatinine (blood)
• DNA, Protozoan (chemistry, genetics)
• Dog Diseases (drug therapy, parasitology)
• Dogs
• Doxycycline (administration & dosage, pharmacology, therapeutic use)
• Drug Combinations
• Drug Therapy, Combination (veterinary)
• Female
• Globulins (analysis)
• Male
• Parasitemia (drug therapy, parasitology, veterinary)
• Polymerase Chain Reaction (veterinary)
• Proguanil (administration & dosage, pharmacology, therapeutic use)
• Serum Albumin (analysis)