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Therapeutic synergism in the treatment of post-stroke arm paresis utilizing botulinum toxin, robotic therapy, and constraint-induced movement therapy.

Abstract
Botulinum toxin type A (BtxA) injection, constraint-induced movement therapy (CIMT), and robotic therapy (RT) each represent promising approaches to enhance arm motor recovery after stroke. To provide more effective treatment for a 50-year-old man with severe left spastic hemiparesis, we attempted to facilitate CIMT with adaptive approaches to extend the wrist and fingers using RT for 10 consecutive weeks after BtxA injection. This combined treatment resulted in substantial improvements in arm function and the amount of arm use in activities of daily living, and may be effective for stroke patients with severe arm paresis. However, we were unable to sufficiently prove the efficacy of combined treatment based only on a single case. To fully elucidate the efficacy of the combined approach for patients with severe hemiparesis after stroke, future studies of a larger number of patients are needed.
AuthorsTakashi Takebayashi, Satoru Amano, Keisuke Hanada, Atsushi Umeji, Kayoko Takahashi, Tetsuo Koyama, Kazuhisa Domen
JournalPM & R : the journal of injury, function, and rehabilitation (PM R) Vol. 6 Issue 11 Pg. 1054-8 (Nov 2014) ISSN: 1934-1563 [Electronic] United States
PMID24880058 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2014 American Academy of Physical Medicine and Rehabilitation. Published by Elsevier Inc. All rights reserved.
Chemical References
  • Neuromuscular Agents
  • Botulinum Toxins, Type A
Topics
  • Activities of Daily Living
  • Botulinum Toxins, Type A (administration & dosage)
  • Exercise Therapy (methods)
  • Humans
  • Injections, Intramuscular
  • Male
  • Middle Aged
  • Neuromuscular Agents (administration & dosage)
  • Paresis (physiopathology, rehabilitation)
  • Recovery of Function
  • Robotics (methods)
  • Time Factors
  • Treatment Outcome
  • Upper Extremity (physiopathology)

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