Abstract | BACKGROUND: MATERIALS AND METHODS: A total of 113 colorectal cancer survivors treated with surgery and/or chemotherapy ± radiotherapy were recruited from medical oncology outpatient clinics during routine follow-up visits in 2012-2013. Bone mineral densitometry (BMD) was performed, and serum 25-OH vitamin D levels were also checked on the same day of the questionnaire. The patients was divided into 2 groups, group A with normal BMD and group B with osteopenia/ osteoporosis. RESULTS: The median age of the study population was 58 (40-76). Thirty (30.0%) were female, whereas 79 (70.0%) were male. The median follow-up was 48 months (14-120 months). Vitamin D deficiency was found in 109 (96.5%); mild deficiency (20-30 ng/ml) in 19 (16.8%), moderate deficiency (10-20 ng/ml) in 54 (47.8%) and severe deficiency (<10 ng/ml) in 36 (31.9%). Osteopenia was evident in 58 (51.4%) patients whereas osteoporosis was noted in 17 (15.0%) . Normal BMD was observed in 38 (33.6%). No apparent effects of type of surgery, presence of stoma, chemotherapy, radiotherapy and TNM stage were found regarding the risk of osteopenia and osteoporosis. Also, the severity of the vitamin D deficiency had no effect in the risk of osteopenia and osteporosis (p=0.93). In female patients, osteopenia/ osteoporosis were observed in 79.5% patients as compared to 60.7% of male patients (p=0.04). CONCLUSIONS:
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Authors | Muhammed Bulent Akinci, Mehmet Ali Nahit Sendur, Sercan Aksoy, Ozan Yazici, Nuriye Yildirim Ozdemir, Tugba Kos, Sebnem Yaman, Kadri Altundag, Nurullah Zengin |
Journal | Asian Pacific journal of cancer prevention : APJCP
(Asian Pac J Cancer Prev)
Vol. 15
Issue 8
Pg. 3377-81
( 2014)
ISSN: 2476-762X [Electronic] Thailand |
PMID | 24870725
(Publication Type: Journal Article)
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Chemical References |
- Vitamin D
- 25-hydroxyvitamin D
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Topics |
- Absorptiometry, Photon
- Adult
- Aged
- Bone Diseases, Metabolic
(blood, complications, diagnostic imaging)
- Cohort Studies
- Colorectal Neoplasms
(blood, complications)
- Female
- Humans
- Male
- Middle Aged
- Osteoporosis
(blood, complications, diagnostic imaging)
- Prospective Studies
- Risk Factors
- Severity of Illness Index
- Survivors
- Vitamin D
(analogs & derivatives, blood)
- Vitamin D Deficiency
(blood, complications)
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