Predicting efficacy of dipeptidyl peptidase-4 inhibitors in patients with type 2 diabetes: Association of glycated hemoglobin reduction with serum eicosapentaenoic acid and docosahexaenoic acid levels.

Abstract

This study was initiated to identify clinical and dietary parameters that predict efficacy of dipeptidyl peptidase-4 inhibitors. A total of 72 untreated Japanese patients with type 2 diabetes who received DPP-4 inhibitors (sitagliptin, alogliptin or vildagliptin) for 4 months were examined for changes of glycated hemoglobin (HbA1c) and body mass index (BMI), and self-administered 3-day food records, as well as serum levels of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). DPP-4 inhibitors significantly reduced HbA1c (before initiation of DPP-4 inhibitors 7.2 ± 0.7%, 4 months after initiation of DPP-4 inhibitors 6.7 ± 0.6% [paired t-test, P < 0.01 vs before]). Multiple regression analysis showed that changes of HbA1c were significantly correlated with baseline HbA1c, as well as estimated intake of fish. Furthermore, changes of HbA1c were significantly correlated with serum levels of EPA (r = -0.624, P < 0.01) and DHA (r = -0.577, P < 0.01). HbA1c reduction by DPP-4 inhibitors is significantly correlated with estimated intake of fish and serum levels of EPA and DHA. (J Diabetes Invest, doi: 10.1111/j.2040-1124.2012.00214.x, 2012).

• Authors: Masahiro Iwasaki, Fuminori Hoshian, Tomoko Tsuji, Naoki Hirose, Tomoko Matsumoto, Naomi Kitatani, Kenji Sugawara, Ryota Usui, Hitoshi Kuwata, Kazu Sugizaki, Yuka Kitamoto, Shuichi Fujiwara, Koin Watanabe, Takanori Hyo, Takeshi Kurose, Yutaka Seino, Daisuke Yabe
• Journal: Journal of diabetes investigation (J Diabetes Investig) Vol. 3 Issue 5 Pg. 464-7 (Oct 18 2012) ISSN: 2040-1116 [Print] Japan
• PMID: 24843607 (Publication Type: Journal Article)