[The mechanism of action of riboxin].

Abstract

The effect of riboxin (100 mg/kg body weight) on different kinds of metabolism in the cardiac muscles of Wistar rats in norm and during experimental pituitrin-neoepinephrine-induced myocardial infarction was studied. Riboxin was found to stimulate anaerobic glycolysis with the hyperproduction of lactate and the formation of glucose deficiency and also to increase the rate of protein synthesis on polyribosomes. Administration of riboxin during the formation of myocardial infarction considerably hinders the pronounced character of its electrocardiographic and biochemical manifestations. Thus, in the ischemic cardiac muscle the pool of macroergic phosphates is preserved, glycolysis and adaptive protein synthesis are impaired to a lesser degree that probably underlies the cardioprotective effect of riboxin.

• Authors: V V Dunaev, V S Tishkin, E I Evdokimov, I M Belaĭ
• Journal: Farmakologiia i toksikologiia (Farmakol Toksikol) 1989 Nov-Dec Vol. 52 Issue 6 Pg. 56-8 ISSN: 0014-8318 [Print] Russia (Federation)
• Vernacular Title: K mekhanizmu deĭstviia riboksina.
• PMID: 2483141 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Inosine Nucleotides
• Pituitary Hormones, Posterior
• Inosine Diphosphate
• Isoproterenol

Topics

• Animals
• Drug Evaluation, Preclinical
• Energy Metabolism (drug effects)
• Female
• Heart (drug effects)
• Inosine Diphosphate (pharmacology, therapeutic use)
• Inosine Nucleotides (pharmacology)
• Isoproterenol
• Male
• Myocardial Infarction (chemically induced, drug therapy, metabolism)
• Myocardium (metabolism)
• Pituitary Hormones, Posterior
• Rats
• Rats, Inbred Strains